RegulonDB RegulonDB 10.10: Gene Form
   

nrdG gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

nrdD tldE nrdG cybC anti-anti-terminator anti-terminator yjgAp5 yjgAp5 yjgAp9 yjgAp9 yjgAp11 yjgAp11 yjgAp8 yjgAp8

Gene      
Name: nrdG    Texpresso search in the literature
Synonym(s): ECK4232, G812, b4237, yjgE
Genome position(nucleotides): 4459900 <-- 4460364 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.97
External database links:  
ASAP:
 ABE-0013860
ECHOBASE:
 EB2414
ECOLIHUB:
 nrdG
OU-MICROARRAY:
 b4237
STRING:
 511145.b4237
COLOMBOS: nrdG


Product      
Name: anaerobic ribonucleoside-triphosphate reductase activating protein
Synonym(s): NrdG, YjgE
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 17.446
Isoelectric point: 7.454
Motif(s):
 
Type Positions Sequence
19 -> 19 C
96 -> 96 C
26 -> 26 C
30 -> 30 C
33 -> 33 C

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.3 - inhibition / activation of enzymes
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031250 - anaerobic ribonucleoside-triphosphate reductase complex
molecular_function GO:0003824 - catalytic activity
GO:0005515 - protein binding
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0051536 - iron-sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0043365 - [formate-C-acetyltransferase]-activating enzyme activity
biological_process GO:0015949 - nucleobase-containing small molecule interconversion
Note(s): Note(s): ...[more].
Reference(s): [1] Fontecave M., et al., 2002
[2] Sun X., et al., 1995
External database links:  
DIP:
 DIP-48068N
ECOCYC:
 RNTRACTIV-MONOMER
ECOLIWIKI:
 b4237
INTERPRO:
 IPR001989
INTERPRO:
 IPR007197
INTERPRO:
 IPR012837
INTERPRO:
 IPR013785
INTERPRO:
 IPR034457
PANTHER:
 PTHR30352:SF2
PANTHER:
 PTHR30352
PFAM:
 PF13353
PRIDE:
 P0A9N8
PRODB:
 PRO_000023407
PROSITE:
 PS01087
REFSEQ:
 NP_418658
SMR:
 P0A9N8
UNIPROT:
 P0A9N8


Operon      
Name: nrdDG         
Operon arrangement:
Transcription unit        Promoter
nrdDG
nrdG


Transcriptional Regulation      
Display Regulation             
Activated by: FNR
Repressed by: H-NS, NrdR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yjgAp8 4458015 reverse nd [ICWHO] [3]
  promoter yjgAp11 4458046 reverse nd [ICWHO] [3]
  promoter yjgAp9 4458065 reverse nd [ICWHO] [3]
  promoter yjgAp5 4458081 reverse nd [ICWHO] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Fontecave M., Mulliez E., Logan DT., 2002, Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase., Prog Nucleic Acid Res Mol Biol 72:95-127

 [2] Sun X., Eliasson R., Pontis E., Andersson J., Buist G., Sjoberg BM., Reichard P., 1995, Generation of the glycyl radical of the anaerobic Escherichia coli ribonucleotide reductase requires a specific activating enzyme., J Biol Chem 270(6):2443-6

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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