Gene
Name:	ampD
Synonym(s):	ECK0109, EG10041, b0110
Genome position(nucleotides):	118733 --> 119284 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.8
External database links:

ASAP:	ABE-0000380
CGSC:	30478
ECHOBASE:	EB0039
ECOLIHUB:	ampD
OU-MICROARRAY:	b0110
STRING:	511145.b0110
COLOMBOS:	ampD

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_232	118078	reverse	nd	[RS-EPT-CBR]	[4]
promoter	ampDp5	118681	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 5.285. P-value: 9.708e-5 Read more >	[ICWHO]	[5]
promoter	TSS_233	120916	reverse	nd	[RS-EPT-CBR]	[4]
promoter	TSS_234 (cluster)	120919	reverse	For this promoter, there is a cluster of 2 transcription start sites,in the interval 120918 to 120919, where the highest frequency is at position 120919. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[4]
promoter	TSS_235	120955	reverse	nd	[RS-EPT-CBR]	[4]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Jacobs C., 1997, Pharmacia Biotech & Science prize. 1997 grand prize winner. Life in the balance: cell walls and antibiotic resistance., Science 278(5344):1731-2
[2] Petrosino JF., Galhardo RS., Morales LD., Rosenberg SM., 2009, Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome., J Bacteriol 191(19):5881-9
[3] Tuomanen E., Lindquist S., Sande S., Galleni M., Light K., Gage D., Normark S., 1991, Coordinate regulation of beta-lactamase induction and peptidoglycan composition by the amp operon., Science 251(4990):201-4
[4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Transcriptional Regulation
	Display Regulation
Repressed by:	CRP