RegulonDB RegulonDB 10.9: Gene Form
   

ampE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aroP nadC ampE ampD CRP TSS_235 TSS_235 TSS_234 (cluster) TSS_234 (cluster) TSS_233 TSS_233 ampD ampD ampDp5 ampDp5 nadCp nadCp TSS_232 TSS_232

Gene      
Name: ampE    Texpresso search in the literature
Synonym(s): ECK0110, EG10042, b0111
Genome position(nucleotides): 119281 --> 120135 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.05
External database links:  
ASAP:
ABE-0000382
CGSC:
30481
ECHOBASE:
EB0040
ECOLIHUB:
ampE
OU-MICROARRAY:
b0111
STRING:
511145.b0111
COLOMBOS: ampE


Product      
Name: protein AmpE
Synonym(s): AmpE
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 32.122
Isoelectric point: 10.058
Motif(s):
 
Type Positions Sequence
44 -> 60 LGMTIIAMGVTFLLLRA
184 -> 198 RLQSGIDAVLHVLDW
261 -> 264 SMAK
74 -> 87 WLLIGLLCIGAGKV
1 -> 284 MTLFTTLLVLIFERLFKLGEHWQLDHRLEAFFRRVKHFSLGRTLGMTIIAMGVTFLLLRALQGVLFNVPTLLVWLLIGLLCIGAGKVRLHYHAYLTAASRNDSHARATMAGELTMIHGVPAGCDEREYLRELQNALLWINFRFYLAPLFWLIVGGTWGPVTLMGYAFLRAWQYWLARYQTPHHRLQSGIDAVLHVLDWVPVRLAGVVYALIGHGEKALPAWFASLGDFHTSQYQVLTRLAQFSLAREPHVDKVETPKAAVSMAKKTSFVVVVVIALLTIYGALV

 

Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0046677 - response to antibiotic
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-47964N
ECOCYC:
EG10042-MONOMER
ECOLIWIKI:
b0111
INTERPRO:
IPR031347
PFAM:
PF17113
PRIDE:
P0AE14
PRODB:
PRO_000022097
REFSEQ:
NP_414653
UNIPROT:
P0AE14


Operon      
Name: ampDE         
Operon arrangement:
Transcription unit        Promoter
ampDE


Transcriptional Regulation      
Display Regulation             
Repressed by: CRP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_232 118078 reverse nd [RS-EPT-CBR] [1]
  promoter ampDp5 118681 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_233 120916 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_234 (cluster) 120919 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_235 120955 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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