RegulonDB RegulonDB 11.1: Gene Form
   

araH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

araG araH otsB otsA araHp7 araHp7 otsBp1 otsBp1 TSS_2235 TSS_2235 otsBp2 otsBp2 otsAp otsAp

Gene      
Name: araH    Texpresso search in the literature
Synonym(s): ECK1897, EG10059, b1898, b1899, b4460
Genome position(nucleotides): 1982554 <-- 1983540
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.17
External database links:  
ASAP:
 ABE-0174093
CGSC:
 18535
ECHOBASE:
 EB0057
ECOLIHUB:
 araH
OU-MICROARRAY:
 b1899
STRING:
 511145.b4460
COLOMBOS: araH


Product      
Name: arabinose ABC transporter membrane subunit
Synonym(s): AraH
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 34.211
Isoelectric point: 9.253
Motif(s):
 
Type Positions Sequence Comment
29 -> 49 VVFAVLFIACAIFVPNFATFI UniProt: Helical.
53 -> 73 GLGLAISMSGMVACGMLFCLA UniProt: Helical.
58 -> 314 ISMSGMVACGMLFCLASGDFDLSVASVIACAGVTTAVVINLTESLWIGVAAGLLLGVLCGLVNGFVIAKLKINALITTLATMQIVRGLAYIISDGKAVGIEDESFFALGYANWFGLPAPIWLTVACLIIFGLLLNKTTFGRNTLAIGGNEEAARLAGVPVVRTKIIIFVLSGLVSAIAGIILASRMTSGQPMTSIGYELIVISACVLGGVSLKGGIGKISYVVAGILILGTVENAMNLLNISPFAQYVVRGLILLAA
79 -> 99 LSVASVIACAGVTTAVVINLT UniProt: Helical.
104 -> 124 IGVAAGLLLGVLCGLVNGFVI UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0022857 - transmembrane transporter activity
GO:0015147 - L-arabinose transmembrane transporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0015751 - arabinose transmembrane transport
GO:0055085 - transmembrane transport
GO:0042882 - L-arabinose transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P0AE26
ECOCYC:
 ARAH-MONOMER
ECOLIWIKI:
 b4460
INTERPRO:
 IPR001851
PFAM:
 PF02653
PRIDE:
 P0AE26
PRODB:
 PRO_000022121
REFSEQ:
 YP_026162
UNIPROT:
 P0AE26


Operon      
Name: araFGH         
Operon arrangement:
Transcription unit        Promoter
araFGH
araFGH
araFGH


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, AraC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2235 1982444 reverse nd [RS-EPT-CBR] [1]
  promoter araHp7 1983560 reverse nd [COMP-AINF] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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