RegulonDB RegulonDB 11.0: Gene Form
   

argA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

recD argA amiC ArgR ArgR TSS_3127 TSS_3127 amiCp6 amiCp6 argAp argAp amiCp7 amiCp7 TSS_3126 TSS_3126

Gene      
Name: argA    Texpresso search in the literature
Synonym(s): Arg1, Arg2, ECK2814, EG10063, b2818
Genome position(nucleotides): 2949242 --> 2950573
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.55
External database links:  
ASAP:
 ABE-0009245
CGSC:
 1021
ECHOBASE:
 EB0061
ECOLIHUB:
 argA
NCBI-GENE:
 947289
OU-MICROARRAY:
 b2818
STRING:
 511145.b2818
COLOMBOS: argA


Product      
Name: N-acetylglutamate synthase
Synonym(s): ArgA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 49.195
Isoelectric point: 6.517
Motif(s):
 
Type Positions Sequence Comment
15 -> 15 H UniProt: In EE17..
19 -> 19 Y UniProt: In EE51..
26 -> 268 KTFVIMLGGEAIEHENFSSIVNDIGLLHSLGIRLVVVYGARPQIDANLAAHHHEPLYHKNIRVTDAKTLELVKQAAGTLQLDITARLSMSLNNTPLQGAHINVVSGNFIIAQPLGVDDGVDYCHSGRIRRIDEDAIHRQLDSGAIVLMGPVAVSVTGESFNLTSEEIATQLAIKLKAEKMIGFCSSQGVTNDDGDIVSELFPNEAQARVEAQEEKGDYNSGTVRFLRGAVKACRSGVRRCHLI
54 -> 54 S UniProt: In PT2M217..
58 -> 58 R UniProt: In EE11..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.3 - arginine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0103045 - methione N-acyltransferase activity
GO:0016740 - transferase activity
GO:0008080 - N-acetyltransferase activity
GO:0016746 - acyltransferase activity
GO:0004042 - acetyl-CoA:L-glutamate N-acetyltransferase activity
GO:0042802 - identical protein binding
GO:0004358 - glutamate N-acetyltransferase activity
biological_process GO:0006526 - arginine biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
External database links:  
ALPHAFOLD:
 P0A6C5
DIP:
 DIP-48037N
ECOCYC:
 N-ACETYLTRANSFER-MONOMER
ECOLIWIKI:
 b2818
INTERPRO:
 IPR000182
INTERPRO:
 IPR001048
INTERPRO:
 IPR016181
INTERPRO:
 IPR036393
INTERPRO:
 IPR033719
INTERPRO:
 IPR010167
MODBASE:
 P0A6C5
PANTHER:
 PTHR30602
PFAM:
 PF00583
PFAM:
 PF00696
PRIDE:
 P0A6C5
PRODB:
 PRO_000022126
PROSITE:
 PS51186
REFSEQ:
 NP_417295
SMR:
 P0A6C5
UNIPROT:
 P0A6C5


Operon      
Name: argA         
Operon arrangement:
Transcription unit        Promoter
argA


Transcriptional Regulation      
Display Regulation             
Repressed by: ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3126 2949064 reverse nd [RS-EPT-CBR] [1]
  promoter amiCp7 2949066 reverse nd [ICWHO] [2]
  promoter amiCp6 2949189 reverse nd [ICWHO] [2]
  promoter TSS_3127 2951765 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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