RegulonDB RegulonDB 10.10: Gene Form
   

argG gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yhbX argG metY ArgR ArgR ArgR CRP Fis TSS_3475 TSS_3475 TSS_3474 (cluster) TSS_3474 (cluster) TSS_3473 TSS_3473 argGp argGp metYp2 metYp2 metYp1 metYp1

Gene      
Name: argG    Texpresso search in the literature
Synonym(s): ECK3161, EG10068, b3172
Genome position(nucleotides): 3318637 --> 3319980 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.6
External database links:  
ASAP:
 ABE-0010428
CGSC:
 1015
ECHOBASE:
 EB0066
ECOLIHUB:
 argG
MIM:
 215700
NCBI-GENE:
 947590
OU-MICROARRAY:
 b3172
STRING:
 511145.b3172
COLOMBOS: argG


Product      
Name: argininosuccinate synthetase
Synonym(s): ArgG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 49.898
Isoelectric point: 5.041
Motif(s):
 
Type Positions Sequence
2 -> 447 TTILKHLPVGQRIGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITDTREKLFGYAKTGLLSSSAASGVPQVENLENKGQ
16 -> 410 IAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYDAIPRRAMEYGAENARLIDCRKQLVAEGIAAIQCGAFHNTTGGLTYFNTTPLGRAVTGTMLVAAMKEDGVNIWGDGSTYKGNDIERFYRYGLLTNAELQIYKPWLDTDFIDELGGRHEMSEFMIACGFDYKMSVEKAYSTDSNMLGATHEAKDLEYLNSSVKIVNPIMGVKFWDESVKIPAEEVTVRFEQGHPVALNGKTFSDDVEMMLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALLHIAYERLLTGIHNEDTIEQYHAHGRQLGRLLYQGRWFDSQALMLRDSLQRWVASQITGEVTLELRRGNDYSILNTVSENLTYKPERLTMEKGDSVFSPDDRIGQLTMRNL
328 -> 328 G
17 -> 25 AFSGGLDTS
220 -> 220 I

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.3 - arginine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016874 - ligase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0004055 - argininosuccinate synthase activity
GO:0042802 - identical protein binding
GO:0042803 - protein homodimerization activity
biological_process GO:0006526 - arginine biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0000050 - urea cycle
GO:0000053 - argininosuccinate metabolic process
External database links:  
DIP:
 DIP-35842N
ECOCYC:
 ARGSUCCINSYN-MONOMER
ECOLIWIKI:
 b3172
INTERPRO:
 IPR023434
INTERPRO:
 IPR023437
INTERPRO:
 IPR024073
INTERPRO:
 IPR018223
INTERPRO:
 IPR024074
INTERPRO:
 IPR001518
INTERPRO:
 IPR014729
PANTHER:
 PTHR11587
PDB:
 1K92
PDB:
 1KP3
PDB:
 1KP2
PDB:
 1K97
PFAM:
 PF00764
PRIDE:
 P0A6E4
PROSITE:
 PS00565
PROSITE:
 PS00564
REFSEQ:
 NP_417640
SMR:
 P0A6E4
UNIPROT:
 P0A6E4


Operon      
Name: argG         
Operon arrangement:
Transcription unit        Promoter
argG


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3473 3318996 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3474 (cluster) 3318998 forward nd [RS-EPT-CBR] [1]
  promoter TSS_3475 3319007 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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