RegulonDB RegulonDB 10.8: Gene Form
   

aroC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aroC prmB mepA smrBp6 smrBp6 TSS_2648 TSS_2648 TSS_2647 (cluster) TSS_2647 (cluster) TSS_2646 TSS_2646 TSS_2645 TSS_2645

Gene      
Name: aroC    Texpresso search in the literature
Synonym(s): ECK2323, EG10075, b2329
Genome position(nucleotides): 2446388 <-- 2447473 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.72
External database links:  
ASAP:
 ABE-0007693
CGSC:
 1006
ECHOBASE:
 EB0073
OU-MICROARRAY:
 b2329
PortEco:
 aroC
STRING:
 511145.b2329
COLOMBOS: aroC


Product      
Name: chorismate synthase
Synonym(s): AroC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 39.137
Isoelectric point: 6.122
Motif(s):
 
Type Positions Sequence
125 -> 127 RSS
10 -> 345 FRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLDIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLL
238 -> 239 NA
2 -> 361 AGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLDIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
293 -> 297 KPTSS

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.20 - chorismate
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016829 - lyase activity
GO:0004107 - chorismate synthase activity
GO:0010181 - FMN binding
GO:0042802 - identical protein binding
biological_process GO:0008652 - cellular amino acid biosynthetic process
GO:0009073 - aromatic amino acid family biosynthetic process
GO:0009423 - chorismate biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 AROC-MONOMER
ECOLIWIKI:
 b2329
INTERPRO:
 IPR020541
INTERPRO:
 IPR000453
INTERPRO:
 IPR035904
MODBASE:
 P12008
PANTHER:
 PTHR21085
PFAM:
 PF01264
PRIDE:
 P12008
PRODB:
 PRO_000022144
PROSITE:
 PS00788
PROSITE:
 PS00789
PROSITE:
 PS00787
REFSEQ:
 NP_416832
SMR:
 P12008
SWISSMODEL:
 P12008
UNIPROT:
 P12008


Operon      
Name: prmB-aroC-mepA-yfcA-epmC-yfcL         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2645 2445745 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2646 2447511 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2647 (cluster) 2447630 reverse For this promoter, there
Read more > 		[RS-EPT-CBR] [1]
  promoter TSS_2648 2448132 reverse nd [RS-EPT-CBR] [1]
  promoter smrBp6 2448436 forward Similarity to the consensus
Read more > 		[ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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