RegulonDB RegulonDB 10.10: Gene Form
   

aroC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aroC prmB mepA smrBp6 smrBp6 TSS_2648 TSS_2648 TSS_2647 (cluster) TSS_2647 (cluster) TSS_2646 TSS_2646 TSS_2645 TSS_2645

Gene      
Name: aroC    Texpresso search in the literature
Synonym(s): ECK2323, EG10075, b2329
Genome position(nucleotides): 2446388 <-- 2447473 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.72
External database links:  
ASAP:
 ABE-0007693
CGSC:
 1006
ECHOBASE:
 EB0073
ECOLIHUB:
 aroC
OU-MICROARRAY:
 b2329
STRING:
 511145.b2329
COLOMBOS: aroC


Product      
Name: chorismate synthase
Synonym(s): AroC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 39.137
Isoelectric point: 6.122
Motif(s):
 
Type Positions Sequence
125 -> 127 RSS
10 -> 345 FRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLDIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLL
238 -> 239 NA
2 -> 361 AGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLAEKFGIEIRGCLTQMGDIPLDIKDWSQVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGILGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
293 -> 297 KPTSS

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.20 - chorismate
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016829 - lyase activity
GO:0004107 - chorismate synthase activity
GO:0010181 - FMN binding
GO:0042802 - identical protein binding
biological_process GO:0008652 - cellular amino acid biosynthetic process
GO:0009073 - aromatic amino acid family biosynthetic process
GO:0009423 - chorismate biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 AROC-MONOMER
ECOLIWIKI:
 b2329
INTERPRO:
 IPR035904
INTERPRO:
 IPR020541
INTERPRO:
 IPR000453
MODBASE:
 P12008
PANTHER:
 PTHR21085
PFAM:
 PF01264
PRIDE:
 P12008
PRODB:
 PRO_000022144
PROSITE:
 PS00787
PROSITE:
 PS00789
PROSITE:
 PS00788
REFSEQ:
 NP_416832
SMR:
 P12008
SWISSMODEL:
 P12008
UNIPROT:
 P12008


Operon      
Name: prmB-aroC-mepA-yfcA-epmC-yfcL         
Operon arrangement:
Transcription unit        Promoter
prmB-aroC-mepA-yfcA-epmC-yfcL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2645 2445745 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2646 2447511 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2647 (cluster) 2447630 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2648 2448132 reverse nd [RS-EPT-CBR] [1]
  promoter smrBp6 2448436 forward nd [ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

RegulonDB