RegulonDB RegulonDB 11.0: Gene Form
   

betB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

betA betB betI betAp5 betAp5 betAp7 betAp7

Gene      
Name: betB    Texpresso search in the literature
Synonym(s): ECK0310, EG10110, b0312
Genome position(nucleotides): 327261 <-- 328733
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 58.25
External database links:  
ASAP:
 ABE-0001072
CGSC:
 17737
ECHOBASE:
 EB0108
ECOLIHUB:
 betB
OU-MICROARRAY:
 b0312
STRING:
 511145.b0312
COLOMBOS: betB


Product      
Name: betaine aldehyde dehydrogenase
Synonym(s): BetB
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 52.911
Isoelectric point: 4.952
Motif(s):
 
Type Positions Sequence Comment
2 -> 490 SRMAEQQLYIHGGYTSATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKIWASMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETSTVDIVTGADVLEYYAGLIPALEGSQIPLRETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDGVFNVLPGVGAETGQYLTEHPGIAKVSFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKAAFEQKILARVERIRAGDVFDPQTNFGPLVSFPHRDNVLRYIAKGKEEGARVLCGGDVLKGDGFDNGAWVAPTVFTDCSDDMTIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSIQVEMAKFQSIF UniProt: Betaine aldehyde dehydrogenase.
17 -> 479 SATSGRTFETINPANGNVLATVQAAGREDVDRAVKSAQQGQKIWASMTAMERSRILRRAVDILRERNDELAKLETLDTGKAYSETSTVDIVTGADVLEYYAGLIPALEGSQIPLRETSFVYTRREPLGVVAGIGAWNYPIQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYSEAGLPDGVFNVLPGVGAETGQYLTEHPGIAKVSFTGGVASGKKVMANSAASSLKEVTMELGGKSPLIVFDDADLDLAADIAMMANFFSSGQVCTNGTRVFVPAKCKAAFEQKILARVERIRAGDVFDPQTNFGPLVSFPHRDNVLRYIAKGKEEGARVLCGGDVLKGDGFDNGAWVAPTVFTDCSDDMTIVREEIFGPVMSILTYESEDEVIRRANDTDYGLAAGIVTADLNRAHRVIHQLEAGICWINTWGESPAEMPVGGYKHSGIGRENGVMTLQSYTQVKSI
150 -> 152 GAW UniProt: NAD.
176 -> 179 KPSE UniProt: NAD.
230 -> 233 GVAS UniProt: NAD.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.18 - betaine biosynthesis
  5 - cell processes --> 5.5 - adaptations --> 5.5.1 - osmotic pressure
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0008802 - betaine-aldehyde dehydrogenase activity
GO:0042802 - identical protein binding
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
biological_process GO:0010165 - response to X-ray
GO:0006970 - response to osmotic stress
GO:0019285 - glycine betaine biosynthetic process from choline
GO:0051289 - protein homotetramerization
Note(s): Note(s): ...[more].
Reference(s): [1] Gonzalez-Segura L., et al., 2013
[2] Lamark T., et al., 1991
[3] Styrvold OB., et al., 1986
External database links:  
ALPHAFOLD:
 P17445
DIP:
 DIP-9208N
ECOCYC:
 BADH-MONOMER
ECOLIWIKI:
 b0312
INTERPRO:
 IPR016163
INTERPRO:
 IPR029510
INTERPRO:
 IPR016162
INTERPRO:
 IPR016161
INTERPRO:
 IPR016160
INTERPRO:
 IPR015590
INTERPRO:
 IPR011264
MODBASE:
 P17445
PFAM:
 PF00171
PRIDE:
 P17445
PRODB:
 PRO_000022208
PROSITE:
 PS00687
PROSITE:
 PS00070
REFSEQ:
 NP_414846
SMR:
 P17445
SWISSMODEL:
 P17445
UNIPROT:
 P17445


Operon      
Name: betIBA         
Operon arrangement:
Transcription unit        Promoter
betIBA


Transcriptional Regulation      
Display Regulation             
Activated by: Cra
Repressed by: BetI, ArcA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter betAp7 327257 reverse nd [ICWHO] [4]
  promoter betAp5 327261 reverse nd [ICWHO] [4]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Gonzalez-Segura L., Riveros-Rosas H., Diaz-Sanchez AG., Julian-Sanchez A., Munoz-Clares RA., 2013, Potential monovalent cation-binding sites in aldehyde dehydrogenases., Chem Biol Interact 202(1-3):41-50

 [2] Lamark T., Kaasen I., Eshoo MW., Falkenberg P., McDougall J., Strom AR., 1991, DNA sequence and analysis of the bet genes encoding the osmoregulatory choline-glycine betaine pathway of Escherichia coli., Mol Microbiol 5(5):1049-64

 [3] Styrvold OB., Falkenberg P., Landfald B., Eshoo MW., Bjornsen T., Strom AR., 1986, Selection, mapping, and characterization of osmoregulatory mutants of Escherichia coli blocked in the choline-glycine betaine pathway., J Bacteriol 165(3):856-63

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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