RegulonDB RegulonDB 11.1: Gene Form
   

cyoE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yajR cyoE cyoD anti-anti-terminator anti-terminator terminator cyoEp3 cyoEp3 TSS_546 TSS_546 yajRp yajRp

Gene      
Name: cyoE    Texpresso search in the literature
Synonym(s): ECK0422, EG10182, b0428
Genome position(nucleotides): 446815 <-- 447705
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.76
External database links:  
ASAP:
 ABE-0001484
CGSC:
 31014
ECHOBASE:
 EB0179
ECOLIHUB:
 cyoE
MIM:
 220110
MIM:
 256000
OU-MICROARRAY:
 b0428
STRING:
 511145.b0428
COLOMBOS: cyoE


Product      
Name: heme O synthase
Synonym(s): CyoE
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 32.248
Isoelectric point: 9.736
Motif(s):
 
Type Positions Sequence Comment
10 -> 28 TKPGIIFGNLISVIGGFLL UniProt: Helical.
19 -> 265 LISVIGGFLLASKGSIDYPLFIYTLVGVSLVVASGCVFNNYIDRDIDRKMERTKNRVLVKGLISPAVSLVYATLLGIAGFMLLWFGANPLACWLGVMGFVVYVGVYSLYMKRHSVYGTLIGSLSGAAPPVIGYCAVTGEFDSGAAILLAIFSLWQMPHSYAIAIFRFKDYQAANIPVLPVVKGISVAKNHITLYIIAFAVATLMLSLGGYAGYKYLVVAAAVSVWWLGMALRGYKVADDRIWARKLF
38 -> 56 LFIYTLVGVSLVVASGCVF UniProt: Helical.
79 -> 97 GLISPAVSLVYATLLGIAG UniProt: Helical.
108 -> 126 LACWLGVMGFVVYVGVYSL UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.6 - aerobic respiration
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016765 - transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016740 - transferase activity
GO:0004311 - farnesyltranstransferase activity
GO:0008495 - protoheme IX farnesyltransferase activity
biological_process GO:0006783 - heme biosynthetic process
GO:0048034 - heme O biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [1] Mogi T., et al., 1994
External database links:  
ALPHAFOLD:
 P0AEA5
DIP:
 DIP-47946N
ECOCYC:
 HEMEOSYN-MONOMER
ECOLIWIKI:
 b0428
ECOO157CYC:
 CYOE-MONOMER
INTERPRO:
 IPR000537
INTERPRO:
 IPR006369
INTERPRO:
 IPR030470
PANTHER:
 PTHR43448
PFAM:
 PF01040
PRIDE:
 P0AEA5
PRODB:
 PRO_000022372
PROSITE:
 PS00943
REFSEQ:
 NP_414962
UNIPROT:
 P0AEA5


Operon      
Name: cyoABCDE         
Operon arrangement:
Transcription unit        Promoter
cyoABCDE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, GadE, CusR, Fis
Repressed by: FNR, Fur, HprR, Cra, ArcA, PdhR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_546 447668 reverse nd [RS-EPT-CBR] [2]
  promoter cyoEp3 447770 reverse nd [COMP-AINF] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Mogi T., Saiki K., Anraku Y., 1994, Biosynthesis and functional role of haem O and haem A., Mol Microbiol 14(3):391-8

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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