RegulonDB RegulonDB 11.0: Gene Form
   

dapD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

glnD dapD yaeI b0165 anti-anti-terminator anti-terminator terminator dapDp dapDp

Gene      
Name: dapD    Texpresso search in the literature
Synonym(s): ECK0164, EG10207, b0166, ssa
Genome position(nucleotides): 185123 <-- 185947
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.09
Reference(s): [1] Richaud C., et al., 1984
External database links:  
ASAP:
 ABE-0000565
CGSC:
 877
ECHOBASE:
 EB0203
ECOLIHUB:
 dapD
ENTREZ:
 K02970
OU-MICROARRAY:
 b0166
STRING:
 511145.b0166
COLOMBOS: dapD


Product      
Name: tetrahydrodipicolinate succinylase
Synonym(s): DapD, Ssa
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 29.892
Isoelectric point: 5.436
Motif(s):
 
Type Positions Sequence Comment
3 -> 69 QLQNIIETAFERRAEITPANADTVTREAVNQVIALLDSGALRVAEKIDGQWVTHQWLKKAVLLSFRI
31 -> 31 V UniProt: In Ref. 1; AAA23667..
163 -> 163 G UniProt: In Ref. 1; AAA23667..
175 -> 209 PTIIEDNCFIGARSEVVEGVIVEEGSVISMGVYIG
177 -> 177 I UniProt: In Ref. 1; AAA23667..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.7 - lysine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016779 - nucleotidyltransferase activity
GO:0016740 - transferase activity
GO:0016746 - acyltransferase activity
GO:0008666 - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
biological_process GO:0008652 - cellular amino acid biosynthetic process
GO:0009085 - lysine biosynthetic process
GO:0009089 - lysine biosynthetic process via diaminopimelate
GO:0019877 - diaminopimelate biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [2] Berges DA., et al., 1986
[3] Degryse E. 1991
[4] Maringanti S., et al., 1999
External database links:  
ALPHAFOLD:
 P0A9D8
DIP:
 DIP-31866N
ECOCYC:
 MONOMER0-2001
ECOLIWIKI:
 b0166
INTERPRO:
 IPR011004
INTERPRO:
 IPR018357
INTERPRO:
 IPR005664
INTERPRO:
 IPR001451
INTERPRO:
 IPR023180
INTERPRO:
 IPR037133
MODBASE:
 P0A9D8
PFAM:
 PF14602
PFAM:
 PF14805
PRIDE:
 P0A9D8
PRODB:
 PRO_000022402
PROSITE:
 PS00101
REFSEQ:
 NP_414708
SMR:
 P0A9D8
SWISSMODEL:
 P0A9D8
UNIPROT:
 P0A9D8


Operon      
Name: map-glnD-dapD         
Operon arrangement:
Transcription unit        Promoter
dapD
glnD
map-glnD-dapD


Transcriptional Regulation      
Display Regulation             
Activated by: ArgP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Richaud C., Richaud F., Martin C., Haziza C., Patte JC., 1984, Regulation of expression and nucleotide sequence of the Escherichia coli dapD gene., J Biol Chem 259(23):14824-8

 [2] Berges DA., DeWolf WE., Dunn GL., Newman DJ., Schmidt SJ., Taggart JJ., Gilvarg C., 1986, Studies on the active site of succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase. Characterization using analogs of tetrahydrodipicolinate., J Biol Chem 261(14):6160-7

 [3] Degryse E., 1991, Polymorphism in the dgt-dapD-tsf region of Escherichia coli K-12 strains., Gene 102(1):141-2

 [4] Maringanti S., Imlay JA., 1999, An intracellular iron chelator pleiotropically suppresses enzymatic and growth defects of superoxide dismutase-deficient Escherichia coli., J Bacteriol 181(12):3792-802

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