RegulonDB RegulonDB 11.1: Gene Form
   

dcp gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dcp ydfG ydeJ ydfGp ydfGp TSS_1848 TSS_1848 dcpp3 dcpp3 TSS_1847 TSS_1847 TSS_1846 TSS_1846

Gene      
Name: dcp    Texpresso search in the literature
Synonym(s): ECK1531, EG10212, b1538
Genome position(nucleotides): 1625335 <-- 1627380
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 49.95
Reference(s): [1] Becker S., et al., 1992
External database links:  
ASAP:
 ABE-0005133
CGSC:
 873
ECHOBASE:
 EB0208
ECOLIHUB:
 dcp
OU-MICROARRAY:
 b1538
STRING:
 511145.b1538
COLOMBOS: dcp


Product      
Name: peptidyl-dipeptidase Dcp
Synonym(s): Dcp, dipeptidyl carboxypeptidase II
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,periplasmic space
Molecular weight: 77.516
Isoelectric point: 5.512
Motif(s):
 
Type Positions Sequence Comment
2 -> 681 TTMNPFLVQSTLPYLAPHFDQIANHHYRPAFDEGMQQKRAEIAAIALNPQMPDFNNTILALEQSGELLTRVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVWQRRESLGLDSESIRLVEVIHQRFVLAGAKLAQADKAKLKVLNTEAATLTSQFNQRLLAANKSGGLVVNDIAQLAGMSEQEIALAAEAAREKGLDNKWLIPLLNTTQQPALAEMRDRATREKLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQMAKTPEAALNFMREIVPAARQRASDELASIQAVIDKQQGGFSAQPWDWAFYAEQVRREKFDLDEAQLKPYFELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPVIYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNASLFNKGYEMSELLSAALLDMRWHCLEENEAMQDVDDFELRALVAENMDLPAIPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGLRFREAILSRGNSEDLERLYRQWRGKAPKIMPMLQHRGLNI UniProt: Dipeptidyl carboxypeptidase.
139 -> 140 IH UniProt: In Ref. 1; CAA41014..
230 -> 678 LAEMRDRATREKLFIAGWTRAEKNDANDTRAIIQRLVEIRAQQATLLGFPHYAAWKIADQMAKTPEAALNFMREIVPAARQRASDELASIQAVIDKQQGGFSAQPWDWAFYAEQVRREKFDLDEAQLKPYFELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDSKSGGAWMGNFVEQSTLNKTHPVIYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLFARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNASLFNKGYEMSELLSAALLDMRWHCLEENEAMQDVDDFELRALVAENMDLPAIPPRYRSSYFAHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGLRFREAILSRGNSEDLERLYRQWRGKAPKIMPMLQHRG

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0030288 - outer membrane-bounded periplasmic space
molecular_function GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0004180 - carboxypeptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0008237 - metallopeptidase activity
biological_process GO:0006508 - proteolysis
Note(s): Note(s): ...[more].
Reference(s): [2] Conlin CA., et al., 1995
[3] Yaron A. 1976
External database links:  
ALPHAFOLD:
 P24171
ECOCYC:
 EG10212-MONOMER
ECOLIWIKI:
 b1538
INTERPRO:
 IPR024077
INTERPRO:
 IPR001567
INTERPRO:
 IPR034005
MODBASE:
 P24171
PDB:
 1Y79
PFAM:
 PF01432
PRIDE:
 P24171
PRODB:
 PRO_000022408
PROSITE:
 PS00142
REFSEQ:
 NP_416056
SMR:
 P24171
SWISSMODEL:
 P24171
UNIPROT:
 P24171


Operon      
Name: dcp         
Operon arrangement:
Transcription unit        Promoter
dcp


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1846 1625884 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_1847 1626295 reverse nd [RS-EPT-CBR] [4]
  promoter dcpp3 1627422 reverse nd [COMP-AINF] [5]
  promoter TSS_1848 1627489 forward nd [RS-EPT-CBR] [4]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Becker S., Plapp R., 1992, Location of the dcp gene on the physical map of Escherichia coli., J Bacteriol 174(5):1698-9

 [2] Conlin CA., Miller CG., 1995, Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium., Methods Enzymol 248:567-79

 [3] Yaron A., 1976, Dipeptidyl carboxypeptidase from Escherichia coli., Methods Enzymol 45:599-610

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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