RegulonDB RegulonDB 11.0: Gene Form
   

dmsA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dmsA serS dmsB Fis ModE IHF NarL Fis NarL NarL Fis FNR dmsCp dmsCp TSS_1098 (cluster) TSS_1098 (cluster) TSS_1097 TSS_1097 TSS_1096 TSS_1096 TSS_1095 TSS_1095 TSS_1094 TSS_1094 dmsAp2 dmsAp2 TSS_1093 TSS_1093 dmsAp1 dmsAp1 TSS_1091 TSS_1091 TSS_1090 TSS_1090 TSS_1089 TSS_1089 TSS_1088 (cluster) TSS_1088 (cluster) TSS_1087 TSS_1087 TSS_1086 TSS_1086

Gene      
Name: dmsA    Texpresso search in the literature
Synonym(s): ECK0885, EG10232, b0894
Genome position(nucleotides): 940959 --> 943403
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.72
Reference(s): [1] Sambasivarao D., et al., 2000
External database links:  
ASAP:
 ABE-0003044
CGSC:
 17710
ECHOBASE:
 EB0228
ECOLIHUB:
 dmsA
OU-MICROARRAY:
 b0894
STRING:
 511145.b0894
COLOMBOS: dmsA


Product      
Name: dimethyl sulfoxide reductase subunit A
Synonym(s): DmsA, dimethyl sulfoxide reductase, chain A
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space,inner membrane
Molecular weight: 90.398
Isoelectric point: 6.854
Motif(s):
 
Type Positions Sequence Comment
1 -> 45 MKTKIPDAVLAAEVSRRGLVKTTAIGGLAMASSALTLPFSRIAHA UniProt: Tat-type signal.
17 -> 17 R UniProt: Not targeted to the membrane, does not support anaerobic growth..
46 -> 814 VDSAIPTKSDEKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPDRLKYPMKRVGARGEGKFERISWEEAYDIIATNMQRLIKEYGNESIYLNYGTGTLGGTMTRSWPPGNTLVARLMNCCGGYLNHYGDYSSAQIAEGLNYTYGGWADGNSPSDIENSKLVVLFGNNPGETRMSGGGVTYYLEQARQKSNARMIIIDPRYTDTGAGREDEWIPIRPGTDAALVNGLAYVMITENLVDQAFLDKYCVGYDEKTLPASAPKNGHYKAYILGEGPDGVAKTPEWASQITGVPADKIIKLAREIGSTKPAFISQGWGPQRHANGEIATRAISMLAILTGNVGINGGNSGAREGSYSLPFVRMPTLENPIQTSISMFMWTDAIERGPEMTALRDGVRGKDKLDVPIKMIWNYAGNCLINQHSEINRTHEILQDDKKCELIVVIDCHMTSSAKYADILLPDCTASEQMDFALDASCGNMSYVIFNDQVIKPRFECKTIYEMTSELAKRLGVEQQFTEGRTQEEWMRHLYAQSREAIPELPTFEEFRKQGIFKKRDPQGHHVAYKAFREDPQANPLTTPSGKIEIYSQALADIAATWELPEGDVIDPLPIYTPGFESYQDPLNKQYPLQLTGFHYKSRVHSTYGNVDVLKAACRQEMWINPLDAQKRGIHNGDKVRIFNDRGEVHIEAKVTPRMMPGVVALGEGAWYDPDAKRVDKGGCINVLTTQRPSPLAKGNPSHTNLVQVEKV UniProt: Dimethyl sulfoxide reductase DmsA.
56 -> 118 EKVIWSACTVNCGSRCPLRMHVVDGEIKYVETDNTGDDNYDGLHQVRACLRGRSMRRRVYNPD UniProt: 4Fe-4S Mo/W bis-MGD-type.
57 -> 57 K UniProt: No alteration of the growth, expression, or catalytic activities..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
  1 - metabolism --> 1.4 - energy production/transport --> 1.4.2 - electron acceptors
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0031237 - intrinsic component of periplasmic side of plasma membrane
GO:0009390 - dimethyl sulfoxide reductase complex
molecular_function GO:0005515 - protein binding
GO:0009055 - electron transfer activity
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0051536 - iron-sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0009389 - dimethyl sulfoxide reductase activity
GO:0030151 - molybdenum ion binding
GO:0043546 - molybdopterin cofactor binding
biological_process GO:0018907 - dimethyl sulfoxide metabolic process
GO:0009061 - anaerobic respiration
GO:0019645 - anaerobic electron transport chain
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P18775
DIP:
 DIP-9452N
ECOCYC:
 DMSA-MONOMER
ECOLIWIKI:
 b0894
INTERPRO:
 IPR006657
INTERPRO:
 IPR006656
INTERPRO:
 IPR006655
INTERPRO:
 IPR006311
INTERPRO:
 IPR009010
INTERPRO:
 IPR011888
INTERPRO:
 IPR027467
INTERPRO:
 IPR019546
INTERPRO:
 IPR006963
MINT:
 P18775
MODBASE:
 P18775
PFAM:
 PF01568
PFAM:
 PF00384
PFAM:
 PF04879
PRIDE:
 P18775
PRODB:
 PRO_000022455
PROSITE:
 PS51669
PROSITE:
 PS00490
PROSITE:
 PS00932
PROSITE:
 PS00551
PROSITE:
 PS51318
REFSEQ:
 NP_415414
SMART:
 SM00926
SMR:
 P18775
UNIPROT:
 P18775


Operon      
Name: dmsABC         
Operon arrangement:
Transcription unit        Promoter
dmsABC
dmsABC
dmsC


Transcriptional Regulation      
Display Regulation             
Activated by: FNR
Repressed by: IHF, NarL, ModE, Fis


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1086 939441 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1087 939732 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1088 (cluster) 939778 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1089 939783 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1090 940085 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1091 940406 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1093 940859 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1094 941064 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1095 941073 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1096 942273 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1097 942295 forward nd [RS-EPT-CBR] [2]
  promoter TSS_1098 (cluster) 943010 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Sambasivarao D., Turner RJ., Simala-Grant JL., Shaw G., Hu J., Weiner JH., 2000, Multiple roles for the twin arginine leader sequence of dimethyl sulfoxide reductase of Escherichia coli., J Biol Chem 275(29):22526-31

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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