RegulonDB

RegulonDB RegulonDB 10.10: Gene Form

dnaQ gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	dnaQ
Synonym(s):	ECK0215, EG10243, b0215, mutD
Genome position(nucleotides):	236067 --> 236798 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.14
External database links:

ASAP:	ABE-0000722
CGSC:	840
ECHOBASE:	EB0239
ECOLIHUB:	dnaQ
OU-MICROARRAY:	b0215
STRING:	511145.b0215
COLOMBOS:	dnaQ

Product

Name:

DNA polymerase III subunit ε

Synonym(s):

DnaQ, MutD

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

27.099

Isoelectric point:

5.626

Motif(s):

Type	Positions	Sequence
	9 -> 175	IVLDTETTGMNQIGAHYEGHKIIEIGAVEVVNRRLTGNNFHVYLKPDRLVDPEAFGVHGIADEFLLDKPTFAEVADEFMDYIRGAELVIHNAAFDIGFMDYEFSLLKRDIPKTNTFCKVTDSLAVARKMFPGKRNSLDALCARYEIDNSKRTLHGALLDAQILAEVY
	183 -> 187	TSMAF

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.1 - DNA related --> 2.1.1 - DNA replication
		2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol GO:0044776 - DNA polymerase III, core complex
	molecular_function	GO:0003676 - nucleic acid binding GO:0003677 - DNA binding GO:0003887 - DNA-directed DNA polymerase activity GO:0016779 - nucleotidyltransferase activity GO:0004518 - nuclease activity GO:0004527 - exonuclease activity GO:0005515 - protein binding GO:0016787 - hydrolase activity GO:0008408 - 3'-5' exonuclease activity GO:0016740 - transferase activity GO:0046872 - metal ion binding
	biological_process	GO:0006260 - DNA replication GO:0045004 - DNA replication proofreading GO:0090305 - nucleic acid phosphodiester bond hydrolysis GO:0071897 - DNA biosynthetic process

Note(s):

Note(s): ...[more].

Reference(s):

[1] DiFrancesco R., et al., 1984
[2] Scheuermann R., et al., 1983

External database links:

DIP:

ECOCYC:

EG10243-MONOMER

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MINT:

MODBASE:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMART:

SMR:

UNIPROT:

Operon

Name:

dnaQ

Operon arrangement:

Transcription unit	Promoter
dnaQ	dnaQp1
dnaQ	dnaQp2
dnaQ

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_431	235937		forward	nd	[RS-EPT-CBR]	[3]
	promoter	TSS_432 (cluster)	236020		forward	nd	[RS-EPT-CBR]	[3]
	promoter	TSS_433	236027		forward	nd	[RS-EPT-CBR]	[3]
	promoter	TSS_435	236931		forward	nd	[RS-EPT-CBR]	[3]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] DiFrancesco R., Bhatnagar SK., Brown A., Bessman MJ., 1984, The interaction of DNA polymerase III and the product of the Escherichia coli mutator gene, mutD., J Biol Chem 259(9):5567-73
[2] Scheuermann R., Tam S., Burgers PM., Lu C., Echols H., 1983, Identification of the epsilon-subunit of Escherichia coli DNA polymerase III holoenzyme as the dnaQ gene product: a fidelity subunit for DNA replication., Proc Natl Acad Sci U S A 80(23):7085-9
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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