RegulonDB RegulonDB 11.0: Gene Form
   

entC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

entE entC fepB Fur Fur Fur Fur Fur Fur CRP Fur Fur Fur Fur CRP RutR entCp entCp fepBp fepBp

Gene      
Name: entC    Texpresso search in the literature
Synonym(s): ECK0586, EG10261, b0593, fepF
Genome position(nucleotides): 624885 --> 626060
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.46
External database links:  
ASAP:
 ABE-0002047
CGSC:
 820
ECHOBASE:
 EB0257
ECOLIHUB:
 entC
OU-MICROARRAY:
 b0593
STRING:
 511145.b0593
COLOMBOS: entC


Product      
Name: isochorismate synthase EntC
Synonym(s): EntC, FepF, isochorismate synthase 1, isochorismate synthase, enterobactin-specific
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 42.932
Isoelectric point: 5.461
Motif(s):
 
Type Positions Sequence Comment
126 -> 380 QTTFEQMVARAAALTATPQVDKVVLSRLIDITTDAAIDSGVLLERLIAQNPVSYNFHVPLADGGVLLGASPELLLRKDGERFSSIPLAGSARRQPDEVLDREAGNRLLASEKDRHEHELVTQAMKEVLRERSSELHVPSSPQLITTPTLWHLATPFEGKANSQENALTLACLLHPTPALSGFPHQAATQVIAELEPFDRELFGGIVGWCDSEGNGEWVVTIRCAKLRENQVRLFAGAGIVPASSPLGEWRETGVK
214 -> 215 GS UniProt: Substrate binding; Sequence Annotation Type: region of interest.
303 -> 303 A UniProt: Loss of mutase activity..
304 -> 304 L UniProt: Loss of mutase activity..
305 -> 306 SG UniProt: In Ref. 1; AAA18491..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.14 - enterochelin (enterobactin)
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016853 - isomerase activity
GO:0046872 - metal ion binding
GO:0008909 - isochorismate synthase activity
GO:0000287 - magnesium ion binding
biological_process GO:0009058 - biosynthetic process
GO:0009239 - enterobactin biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [1] He Z., et al., 2006
External database links:  
ALPHAFOLD:
 P0AEJ2
DIP:
 DIP-47970N
ECOCYC:
 ENTC-MONOMER
ECOLIWIKI:
 b0593
INTERPRO:
 IPR005801
INTERPRO:
 IPR015890
INTERPRO:
 IPR004561
MODBASE:
 P0AEJ2
PDB:
 5JXZ
PDB:
 5JY4
PDB:
 5JY8
PDB:
 5JZD
PDB:
 3HWO
PFAM:
 PF00425
PRIDE:
 P0AEJ2
PRODB:
 PRO_000022521
REFSEQ:
 NP_415125
SMR:
 P0AEJ2
UNIPROT:
 P0AEJ2


Operon      
Name: entCEBAH         
Operon arrangement:
Transcription unit        Promoter
entCEBA-ybdB
entH


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: Fur


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] He Z., Toney MD., 2006, Direct detection and kinetic analysis of covalent intermediate formation in the 4-amino-4-deoxychorismate synthase catalyzed reaction., Biochemistry 45(15):5019-28

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