RegulonDB RegulonDB 11.1: Gene Form
   

accC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

accC accB yhdT panF terminator anti-anti-terminator anti-terminator yhdTp yhdTp

Gene      
Name: accC    Texpresso search in the literature
Synonym(s): ECK3243, EG10276, b3256, fabG
Genome position(nucleotides): 3405917 --> 3407266
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.41
External database links:  
ASAP:
 ABE-0010677
CGSC:
 29834
ECHOBASE:
 EB0272
ECOLIHUB:
 accC
MIM:
 210200
OU-MICROARRAY:
 b3256
STRING:
 511145.b3256
COLOMBOS: accC


Product      
Name: biotin carboxylase
Synonym(s): AccC, FabG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 49.321
Isoelectric point: 7.117
Motif(s):
 
Type Positions Sequence Comment
1 -> 445 MLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETVCIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSGFIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLPSPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAIARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLG UniProt: Biotin carboxylation.
19 -> 19 R UniProt: Loss of homodimerization. No effect on ATP binding..
23 -> 23 E UniProt: Loss of homodimerization. No effect on ATP binding..
115 -> 323 DKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAAGQPLSI
120 -> 317 IAAMKKAGVPCVPGSDGPLGDDMDKNRAIAKRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVYMEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGITPELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIEMNTRIQVEHPVTEMITGVDLIKEQLRIAA UniProt: ATP-grasp.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.4 - fatty acids and phosphatidic acid
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009317 - acetyl-CoA carboxylase complex
molecular_function GO:0005515 - protein binding
GO:0046872 - metal ion binding
GO:0016874 - ligase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0003989 - acetyl-CoA carboxylase activity
GO:0004075 - biotin carboxylase activity
GO:0042803 - protein homodimerization activity
biological_process GO:0006629 - lipid metabolic process
GO:0006631 - fatty acid metabolic process
GO:0006633 - fatty acid biosynthetic process
GO:0045717 - negative regulation of fatty acid biosynthetic process
GO:2001295 - malonyl-CoA biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P24182
DIP:
 DIP-9035N
ECOCYC:
 BIOTIN-CARBOXYL-MONOMER
ECOLIWIKI:
 b3256
INTERPRO:
 IPR005482
INTERPRO:
 IPR016185
INTERPRO:
 IPR005479
INTERPRO:
 IPR004549
INTERPRO:
 IPR005481
INTERPRO:
 IPR011054
INTERPRO:
 IPR011761
INTERPRO:
 IPR011764
INTERPRO:
 IPR013815
MODBASE:
 P24182
PDB:
 2W6Q
PDB:
 2W6Z
PDB:
 2W70
PDB:
 2W71
PDB:
 3G8C
PDB:
 3G8D
PDB:
 3JZF
PDB:
 3JZI
PDB:
 3RUP
PDB:
 3RV3
PDB:
 3RV4
PDB:
 4HR7
PDB:
 6OI9
PDB:
 2W6P
PDB:
 2W6O
PDB:
 2W6N
PDB:
 2W6M
PDB:
 2VR1
PDB:
 2V5A
PDB:
 2V59
PDB:
 2V58
PDB:
 2J9G
PDB:
 2GPW
PDB:
 2GPS
PDB:
 1K69
PDB:
 1DV2
PDB:
 1BNC
PDB:
 1DV1
PFAM:
 PF02786
PFAM:
 PF02785
PFAM:
 PF00289
PRIDE:
 P24182
PRODB:
 PRO_000022034
PROSITE:
 PS00866
PROSITE:
 PS50975
PROSITE:
 PS50979
PROSITE:
 PS00867
REFSEQ:
 NP_417722
SMART:
 SM00878
SMR:
 P24182
UNIPROT:
 P24182


Operon      
Name: accBC         
Operon arrangement:
Transcription unit        Promoter
accBC
accBC


Transcriptional Regulation      
Display Regulation             
Activated by: FadR
Repressed by: AccB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



RegulonDB