RegulonDB RegulonDB 11.1: Gene Form
   

fecD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

fecC fecD fecB fecE fecEp4 fecEp4 fecEp5 fecEp5 fecEp3 fecEp3

Gene      
Name: fecD    Texpresso search in the literature
Synonym(s): ECK4278, EG10289, b4288
Genome position(nucleotides): 4511458 <-- 4512414
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 59.77
External database links:  
ASAP:
 ABE-0014059
CGSC:
 18394
ECHOBASE:
 EB0285
ECOLIHUB:
 fecD
ECOO157CYC:
 Z4384
ECOO157CYC:
 CHUU
ECOO157CYC:
 Z1965
OU-MICROARRAY:
 b4288
STRING:
 511145.b4288
COLOMBOS: fecD


Product      
Name: ferric citrate ABC transporter membrane subunit FecD
Synonym(s): FecD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 34.131
Isoelectric point: 10.365
Motif(s):
 
Type Positions Sequence Comment
3 -> 23 IALVIFITLALAGCALLSLHM UniProt: Helical.
14 -> 316 AGCALLSLHMGVIPVPWRALLTDWQAGHEHYYVLMEYRLPRLLLALFVGAALAVAGVLIQGIVRNPLASPDILGVNHAASLASVGALLLMPSLPVMVLPLLAFAGGMAGLILLKMLAKTHQPMKLALTGVALSACWASLTDYLMLSRPQDVNNALLWLTGSLWGRDWSFVKIAIPLMILFLPLSLSFCRDLDLLALGDARATTLGVSVPHTRFWALLLAVAMTSTGVAACGPISFIGLVVPHMMRSITGGRHRRLLPVSALTGALLLVVADLLARIIHPPLELPVGVLTAIIGAPWFVWLLVR
41 -> 41 H UniProt: In Ref. 1; AAA23764..
56 -> 76 LLALFVGAALAVAGVLIQGIV UniProt: Helical.
85 -> 105 ILGVNHAASLASVGALLLMPS UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0005515 - protein binding
GO:0015603 - iron chelate transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0006811 - ion transport
GO:0055072 - iron ion homeostasis
GO:0055085 - transmembrane transport
GO:0033212 - iron import into cell
GO:0033214 - siderophore-dependent iron import into cell
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P15029
ECOCYC:
 FECD-MONOMER
ECOLIWIKI:
 b4288
ECOO157CYC:
 Z1965-MONOMER
ECOO157CYC:
 Z4384-MONOMER
ECOO157CYC:
 CHUU-MONOMER
INTERPRO:
 IPR000522
INTERPRO:
 IPR037294
MODBASE:
 P15029
PANTHER:
 PTHR30472
PFAM:
 PF01032
PRIDE:
 P15029
PRODB:
 PRO_000022594
REFSEQ:
 NP_418708
SMR:
 P15029
UNIPROT:
 P15029


Operon      
Name: fecABCDE         
Operon arrangement:
Transcription unit        Promoter
fecABCDE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, PdhR
Repressed by: Fur, HypT


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter fecEp3 4511530 reverse nd [COMP-AINF] [1]
  promoter fecEp5 4511639 reverse nd [COMP-AINF] [1]
  promoter fecEp4 4511644 reverse nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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