RegulonDB RegulonDB 11.1: Gene Form
   

fepB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

entS entC fepB Fur Fur Fur Fur Fur Fur CRP Fur Fur Fur Fur CRP RutR entCp entCp fepBp fepBp

Gene      
Name: fepB    Texpresso search in the literature
Synonym(s): ECK0585, EG10294, b0592
Genome position(nucleotides): 623554 <-- 624510
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.07
External database links:  
ASAP:
 ABE-0002038
CGSC:
 18385
ECHOBASE:
 EB0290
ECOLIHUB:
 fepB
OU-MICROARRAY:
 b0592
STRING:
 511145.b0592
COLOMBOS: fepB


Product      
Name: ferric enterobactin ABC transporter periplasmic binding protein
Synonym(s): FepB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 34.283
Isoelectric point: 6.033
Motif(s):
 
Type Positions Sequence Comment
1 -> 26 MRLAPLYRNALLLTGLLLSGIAAVQA
27 -> 318 ADWPRQITDSRGTHTLESQPQRIVSTSVTLTGSLLAIDAPVIASGATTPNNRVADDQGFLRQWSKVAKERKLQRLYIGEPSAEAVAAQMPDLILISATGGDSALALYDQLSTIAPTLIINYDDKSWQSLLTQLGEITGHEKQAAERIAQFDKQLAAAKEQIKLPPQPVTAIVYTAAAHSANLWTPESAQGQMLEQLGFTLAKLPAGLNASQSQGKRHDIIQLGGENLAAGLNGESLFLFAGDQKDADAIYANPLLAHLPAVQNKQVYALGTETFRLDYYSAMQVLDRLKALF UniProt: Ferrienterobactin-binding periplasmic protein.
48 -> 318 RIVSTSVTLTGSLLAIDAPVIASGATTPNNRVADDQGFLRQWSKVAKERKLQRLYIGEPSAEAVAAQMPDLILISATGGDSALALYDQLSTIAPTLIINYDDKSWQSLLTQLGEITGHEKQAAERIAQFDKQLAAAKEQIKLPPQPVTAIVYTAAAHSANLWTPESAQGQMLEQLGFTLAKLPAGLNASQSQGKRHDIIQLGGENLAAGLNGESLFLFAGDQKDADAIYANPLLAHLPAVQNKQVYALGTETFRLDYYSAMQVLDRLKALF UniProt: Fe/B12 periplasmic-binding.
78 -> 297 RVADDQGFLRQWSKVAKERKLQRLYIGEPSAEAVAAQMPDLILISATGGDSALALYDQLSTIAPTLIINYDDKSWQSLLTQLGEITGHEKQAAERIAQFDKQLAAAKEQIKLPPQPVTAIVYTAAAHSANLWTPESAQGQMLEQLGFTLAKLPAGLNASQSQGKRHDIIQLGGENLAAGLNGESLFLFAGDQKDADAIYANPLLAHLPAVQNKQVYALGT

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.7 - Fe aquisition
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.p - ABC superfamily, periplasmic binding component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:1903981 - enterobactin binding
biological_process GO:0006811 - ion transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0055072 - iron ion homeostasis
GO:0033212 - iron import into cell
GO:0015685 - ferric-enterobactin import into cell
Note(s): Note(s): ...[more].
Reference(s): [1] Chu BC., et al., 2011
External database links:  
ALPHAFOLD:
 P0AEL6
DIP:
 DIP-9593N
ECOCYC:
 FEPB-MONOMER
ECOLIWIKI:
 b0592
INTERPRO:
 IPR002491
MODBASE:
 P0AEL6
PDB:
 3TLK
PDB:
 2M6K
PDB:
 2M6L
PFAM:
 PF01497
PRIDE:
 P0AEL6
PRODB:
 PRO_000022601
PROSITE:
 PS50983
REFSEQ:
 NP_415124
SMR:
 P0AEL6
UNIPROT:
 P0AEL6


Operon      
Name: fepB         
Operon arrangement:
Transcription unit        Promoter
fepB


Transcriptional Regulation      
Display Regulation             
Repressed by: Fur, RutR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Chu BC., Vogel HJ., 2011, A structural and functional analysis of type III periplasmic and substrate binding proteins: their role in bacterial siderophore and heme transport., Biol Chem 392(1-2):39-52

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