RegulonDB RegulonDB 11.1: Gene Form
   

fliC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

fliC fliD fliX FlhDC FlhDC NsrR IHF IHF anti-anti-terminator anti-terminator terminator TSS_2265 TSS_2265 fliDp2 fliDp2 fliCp fliCp TSS_2264 TSS_2264 TSS_2263 TSS_2263 TSS_2262 TSS_2262 TSS_2261 TSS_2261

Gene      
Name: fliC    Texpresso search in the literature
Synonym(s): ECK1922, EG10321, H, b1923, flaF, hag
Genome position(nucleotides): 2002110 <-- 2003606
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 47.49
External database links:  
ASAP:
 ABE-0006402
CGSC:
 649
ECHOBASE:
 EB0317
ECOLIHUB:
 fliC
OU-MICROARRAY:
 b1923
STRING:
 511145.b1923
COLOMBOS: fliC


Product      
Name: flagellar filament structural protein
Synonym(s): FlaF, FliC, Hag, flagellin
Sequence: Get amino acid sequence Fasta Format
Cellular location: extracellular space,cell projection
Molecular weight: 51.295
Isoelectric point: 4.291
Motif(s):
 
Type Positions Sequence Comment
2 -> 498 AQVINTNSLSLITQNNINKNQSALSSSIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQAARNANDGISVAQTTEGALSEINNNLQRVRELTVQATTGTNSESDLSSIQDEIKSRLDEIDRVSGQTQFNGVNVLAKNGSMKIQVGANDNQTITIDLKQIDAKTLGLDGFSVKNNDTVTTSAPVTAFGATTTNNIKLTGITLSTEAATDTGGTNPASIEGVYTDNGNDYYAKITGGDNDGKYYAVTVANDGTVTMATGATANATVTDANTTKATTITSGGTPVQIDNTAGSATANLGAVSLVKLQDSKGNDTDTYALKDTNGNLYAADVNETTGAVSVKTITYTDSSGAASSPTAVKLGGDDGKTEVVDIDGKTYDSADLNGGNLQTGLTAGGEALTAVANGKTTDPLKALDDAIASVDKFRSSLGAVQNRLDSAVTNLNNTTTNLSEAQSRIQDADYATEVSNMSKAQIIQQAGNSVLAKANQVPQQVLSLLQG UniProt: Flagellin.
5 -> 141 INTNSLSLITQNNINKNQSALSSSIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQAARNANDGISVAQTTEGALSEINNNLQRVRELTVQATTGTNSESDLSSIQDEIKSRLDEIDRVSGQTQFNGVNVLAKN
198 -> 276 IKLTGITLSTEAATDTGGTNPASIEGVYTDNGNDYYAKITGGDNDGKYYAVTVANDGTVTMATGATANATVTDANTTKA
285 -> 285 P UniProt: In Ref. 2; CAA35488..
411 -> 496 LKALDDAIASVDKFRSSLGAVQNRLDSAVTNLNNTTTNLSEAQSRIQDADYATEVSNMSKAQIIQQAGNSVLAKANQVPQQVLSLL

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.12 - flagellum
  5 - cell processes --> 5.3 - motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc)
  6 - cell structure --> 6.4 - flagella
Gene Ontology Terms (GO)  
cellular_component GO:0005576 - extracellular region
GO:0009288 - bacterial-type flagellum
molecular_function GO:0005198 - structural molecule activity
GO:0005515 - protein binding
Note(s): Note(s): ...[more].
Reference(s): [1] Blackburn SA., et al., 2021
External database links:  
ALPHAFOLD:
 P04949
DIP:
 DIP-9649N
ECOCYC:
 EG10321-MONOMER
ECOLIWIKI:
 b1923
INTERPRO:
 IPR001492
INTERPRO:
 IPR001029
INTERPRO:
 IPR014981
MODBASE:
 P04949
PFAM:
 PF08884
PFAM:
 PF00669
PFAM:
 PF00700
PRIDE:
 P04949
PRINTS:
 PR00207
PRODB:
 PRO_000022655
REFSEQ:
 NP_416433
SMR:
 P04949
UNIPROT:
 P04949


Operon      
Name: fliCX         
Operon arrangement:
Transcription unit        Promoter
fliC


Transcriptional Regulation      
Display Regulation             
Activated by: H-NS, GadE
Repressed by: MatA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2261 2002392 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2262 2002401 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2263 2003300 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2264 2003675 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_2265 2003836 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Blackburn SA., Shepherd M., Robinson GK., 2021, Reciprocal Packaging of the Main Structural Proteins of Type 1 Fimbriae and Flagella in the Outer Membrane Vesicles of "Wild Type" Escherichia coli Strains., Front Microbiol 12:557455

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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