RegulonDB RegulonDB 10.10: Gene Form
   

fucO gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

fucO ygdG fucA fucOp fucOp

Gene      
Name: fucO    Texpresso search in the literature
Synonym(s): ECK2794, EG10351, b2799
Genome position(nucleotides): 2931865 <-- 2933013 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.52
External database links:  
ASAP:
 ABE-0009177
CGSC:
 17698
ECHOBASE:
 EB0347
ECOLIHUB:
 fucO
OU-MICROARRAY:
 b2799
STRING:
 511145.b2799
COLOMBOS: fucO


Product      
Name: L-1,2-propanediol oxidoreductase
Synonym(s): FucO
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 40.513
Isoelectric point: 4.902
Motif(s):
 
Type Positions Sequence
38 -> 38 D
96 -> 96 G
199 -> 199 H
1 -> 9 MANRMILNE
139 -> 143 TTAGT

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.25 - glycolate metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0052661 - S-lactaldehyde reductase activity
GO:0052660 - R-lactaldehyde reductase activity
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0004022 - alcohol dehydrogenase (NAD+) activity
GO:0008198 - ferrous iron binding
GO:0008912 - lactaldehyde reductase activity
GO:0042803 - protein homodimerization activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0019301 - rhamnose catabolic process
GO:0006004 - fucose metabolic process
GO:0019317 - fucose catabolic process
GO:0042355 - L-fucose catabolic process
GO:0042846 - glycol catabolic process
GO:0051143 - propanediol metabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Lee DH., et al., 2010
[2] Wang X., et al., 2011
External database links:  
DIP:
 DIP-48076N
ECOCYC:
 LACTALDREDUCT-MONOMER
ECOLIWIKI:
 b2799
INTERPRO:
 IPR001670
INTERPRO:
 IPR013460
INTERPRO:
 IPR018211
INTERPRO:
 IPR039697
MODBASE:
 P0A9S1
PANTHER:
 PTHR11496
PDB:
 2BL4
PDB:
 2BI4
PDB:
 1RRM
PDB:
 5BR4
PFAM:
 PF00465
PRIDE:
 P0A9S1
PRODB:
 PRO_000022730
PROSITE:
 PS00913
PROSITE:
 PS00060
REFSEQ:
 NP_417279
SMR:
 P0A9S1
UNIPROT:
 P0A9S1


Operon      
Name: fucAO         
Operon arrangement:
Transcription unit        Promoter
fucO
fucAO


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, FucR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Lee DH., Palsson BO., 2010, Adaptive evolution of Escherichia coli K-12 MG1655 during growth on a Nonnative carbon source, L-1,2-propanediol., Appl Environ Microbiol 76(13):4158-68

 [2] Wang X., Miller EN., Yomano LP., Zhang X., Shanmugam KT., Ingram LO., 2011, Increased furfural tolerance due to overexpression of NADH-dependent oxidoreductase FucO in Escherichia coli strains engineered for the production of ethanol and lactate., Appl Environ Microbiol 77(15):5132-40

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