RegulonDB RegulonDB 11.1: Gene Form
   

glgA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

glgP glgX glgA glgC glgB ppGpp ppGpp anti-anti-terminator anti-terminator TSS_4043 TSS_4043 TSS_4042 TSS_4042 TSS_4041 TSS_4041 glgCp3 glgCp3 TSS_4040 (cluster) TSS_4040 (cluster) glgCp2 glgCp2 glgCp1 glgCp1 TSS_4039 TSS_4039 TSS_4038 TSS_4038 TSS_4037 TSS_4037 TSS_4036 TSS_4036 TSS_4035 TSS_4035 TSS_4034 TSS_4034 glgAp glgAp TSS_4033 TSS_4033 TSS_4032 TSS_4032 TSS_4031 TSS_4031 glgPp1 glgPp1 TSS_4030 TSS_4030 TSS_4029 TSS_4029 TSS_4028 TSS_4028 TSS_4027 TSS_4027

Gene      
Name: glgA    Texpresso search in the literature
Synonym(s): ECK3415, EG10377, b3429
Genome position(nucleotides): 3566600 <-- 3568033
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.95
Note(s): In a gene expression analysis, RpoS positively regulated glgA gene in the stationary phase. Its effect could be indirect Becker-Hapak M,1995.
External database links:  
ASAP:
 ABE-0011200
CGSC:
 710
ECHOBASE:
 EB0372
ECOLIHUB:
 glgA
OU-MICROARRAY:
 b3429
STRING:
 511145.b3429
COLOMBOS: glgA


Product      
Name: glycogen synthase
Synonym(s): GlgA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 52.822
Isoelectric point: 6.62
Motif(s):
 
Type Positions Sequence Comment
2 -> 233 QVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDARVLLPAFPDIRRGVTDAQVVSRRDTFAGHITLLFGHYNGVGIYLIDAPHLYDRPGSPYHDTNLFAYTDNVLRFALLGWVGAEMASGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAHHMNDIQLPWSFFNIHGLEFNGQISFLKAGLYYADHITAVSPTYAREITEPQFAYGMEGLLQ
63 -> 63 F UniProt: In Ref. 1; AAA23870..
102 -> 103 AY UniProt: In Ref. 1; AAA23870..
245 -> 245 L UniProt: In Ref. 1; AAA23870..
280 -> 280 L UniProt: In Ref. 1; AAA23870..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.9 - cytoplasmic polysaccharides
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016757 - glycosyltransferase activity
GO:0016740 - transferase activity
GO:0009011 - starch synthase activity
GO:0004373 - glycogen (starch) synthase activity
GO:0033201 - alpha-1,4-glucan synthase activity
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0005978 - glycogen biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P0A6U8
ECOCYC:
 GLYCOGENSYN-MONOMER
ECOLIWIKI:
 B3429
INTERPRO:
 IPR011835
INTERPRO:
 IPR013534
INTERPRO:
 IPR001296
MODBASE:
 P0A6U8
PDB:
 3GUH
PDB:
 3CX4
PDB:
 3COP
PDB:
 3D1J
PDB:
 2QZS
PDB:
 2R4T
PDB:
 2R4U
PFAM:
 PF00534
PFAM:
 PF08323
PRIDE:
 P0A6U8
PRODB:
 PRO_000022776
REFSEQ:
 NP_417887
SMR:
 P0A6U8
SWISSMODEL:
 P0A6U8
UNIPROT:
 P0A6U8


Operon      
Name: glgBXCAP         
Operon arrangement:
Transcription unit        Promoter
glgAP
glgCAP
glgCAP
glgCAP
glgBXCAP


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, PhoP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4027 3564324 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4028 3565337 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4029 3565453 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4030 3566562 reverse nd [RS-EPT-CBR] [1]
  promoter glgPp1 3566773 reverse nd [COMP-AINF] [2]
  promoter TSS_4031 3567478 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4032 3567563 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4033 3567895 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4034 3568396 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4035 3568634 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4036 3568661 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4037 3568712 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4038 3568714 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4039 3569225 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4040 (cluster) 3569457 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4041 3570215 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4042 3570251 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_4043 3570750 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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