RegulonDB RegulonDB 11.1: Gene Form
   

guaC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hofC guaC b0105 yacM hofB TSS_231 TSS_231 TSS_230 TSS_230

Gene      
Name: guaC    Texpresso search in the literature
Synonym(s): ECK0104, EG10422, b0104
Genome position(nucleotides): 113444 --> 114487
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.34
External database links:  
ASAP:
 ABE-0000362
CGSC:
 655
ECHOBASE:
 EB0417
ECOLIHUB:
 guaC
OU-MICROARRAY:
 b0104
STRING:
 511145.b0104
COLOMBOS: guaC


Product      
Name: GMP reductase
Synonym(s): GMPR, GuaC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 37.384
Isoelectric point: 6.517
Motif(s):
 
Type Positions Sequence Comment
9 -> 338 LGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYSVEEWQAFINNSSADVLKHVMVSTGTSDADFEKTKQILDLNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQE
108 -> 131 ADFEKTKQILDLNPALNFVCIDVA UniProt: NADP.
216 -> 239 IVSDGGCTTPGDVAKAFGGGADFV UniProt: NADP.
233 -> 235 GGG UniProt: In Ref. 1 and 2..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.33 - nucleotide and nucleoside conversions
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:1902560 - GMP reductase complex
molecular_function GO:0003824 - catalytic activity
GO:0005515 - protein binding
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0003920 - GMP reductase activity
GO:0042802 - identical protein binding
biological_process GO:0006163 - purine nucleotide metabolic process
GO:0009117 - nucleotide metabolic process
GO:0015951 - purine ribonucleotide interconversion
GO:0032264 - IMP salvage
External database links:  
ALPHAFOLD:
 P60560
DIP:
 DIP-47861N
ECOCYC:
 GMP-REDUCT-MONOMER
ECOLIWIKI:
 b0104
INTERPRO:
 IPR013785
INTERPRO:
 IPR015875
INTERPRO:
 IPR005993
INTERPRO:
 IPR001093
MODBASE:
 P60560
PFAM:
 PF00478
PRIDE:
 P60560
PRODB:
 PRO_000022852
PROSITE:
 PS00487
REFSEQ:
 NP_414646
SMR:
 P60560
SWISSMODEL:
 P60560
UNIPROT:
 P60560


Operon      
Name: guaC         
Operon arrangement:
Transcription unit        Promoter
guaC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_230 113394 forward nd [RS-EPT-CBR] [1]
  promoter TSS_231 113396 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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