RegulonDB RegulonDB 10.10: Gene Form
   

gyrA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gyrA yfaA ubiG yfaT CspA CspA CspA Fis anti-anti-terminator anti-terminator terminator TSS_2508 (cluster) TSS_2508 (cluster) ubiGp ubiGp gyrAp gyrAp TSS_2505 TSS_2505 TSS_2504 TSS_2504 TSS_2503 TSS_2503 TSS_2502 TSS_2502

Gene      
Name: gyrA    Texpresso search in the literature
Synonym(s): ECK2223, EG10423, b2231, hisW, nalA, nfxA, norA, parD
Genome position(nucleotides): 2336793 <-- 2339420 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.0
External database links:  
ASAP:
 ABE-0007370
CGSC:
 651
ECHOBASE:
 EB0418
ECOLIHUB:
 gyrA
OU-MICROARRAY:
 b2231
STRING:
 511145.b2231
COLOMBOS: gyrA


Product      
Name: DNA gyrase subunit A
Synonym(s): GyrA, HisW, NalA, NfxA, NorA, ParD
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,membrane
Molecular weight: 96.963
Isoelectric point: 4.825
Motif(s):
 
Type Positions Sequence
80 -> 80 H
87 -> 87 D
560 -> 566 QRRGGKG
798 -> 798 I
83 -> 83 S

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.1 - DNA related --> 2.1.1 - DNA replication
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0005694 - chromosome
GO:0009330 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
molecular_function GO:0003677 - DNA binding
GO:0003916 - DNA topoisomerase activity
GO:0005515 - protein binding
GO:0008094 - ATP-dependent activity, acting on DNA
GO:0016853 - isomerase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0042802 - identical protein binding
GO:0034335 - DNA negative supercoiling activity
biological_process GO:0006259 - DNA metabolic process
GO:0006261 - DNA-dependent DNA replication
GO:0006351 - transcription, DNA-templated
GO:0009410 - response to xenobiotic stimulus
GO:0046677 - response to antibiotic
GO:0006265 - DNA topological change
External database links:  
DIP:
 DIP-36179N
ECOCYC:
 EG10423-MONOMER
ECOLIWIKI:
 b2231
INTERPRO:
 IPR002205
INTERPRO:
 IPR035516
INTERPRO:
 IPR013760
INTERPRO:
 IPR005743
INTERPRO:
 IPR006691
INTERPRO:
 IPR013757
INTERPRO:
 IPR013758
MINT:
 P0AES4
MODBASE:
 P0AES4
PDB:
 1ZI0
PDB:
 6RKU
PDB:
 6RKW
PDB:
 6RKS
PDB:
 6RKV
PDB:
 2Y3P
PDB:
 3NUH
PDB:
 1AB4
PDB:
 1X75
PDB:
 4ELY
PFAM:
 PF00521
PFAM:
 PF03989
PRIDE:
 P0AES4
PRODB:
 PRO_000022855
REFSEQ:
 NP_416734
SMART:
 SM00434
SMR:
 P0AES4
SWISSMODEL:
 P0AES4
UNIPROT:
 P0AES4


Operon      
Name: gyrA         
Operon arrangement:
Transcription unit        Promoter
gyrA


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, CspA
Repressed by: Fis


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2502 2338373 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2503 2338375 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2504 2338445 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2505 2338825 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2508 (cluster) 2339547 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB