RegulonDB RegulonDB 11.0: Gene Form
   

hemH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gsk hemH aes adk OxyR OxyR aesp aesp gskp gskp TSS_643 TSS_643 TSS_642 TSS_642 hemHp hemHp

Gene      
Name: hemH    Texpresso search in the literature
Synonym(s): ECK0469, EG10431, b0475, popA, visA
Genome position(nucleotides): 498055 --> 499017
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.89
External database links:  
ASAP:
 ABE-0001649
CGSC:
 641
ECHOBASE:
 EB0426
ECOLIHUB:
 hemH
MIM:
 177000
OU-MICROARRAY:
 b0475
STRING:
 511145.b0475
COLOMBOS: hemH


Product      
Name: ferrochelatase
Synonym(s): HemH, PopA, VisA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 35.884
Isoelectric point: 6.634
Motif(s):
 
Type Positions Sequence Comment
5 -> 317 KTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPEMPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVA
54 -> 54 L UniProt: In Ref. 1; BAA14304..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.12 - heme, porphyrine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016829 - lyase activity
GO:0046872 - metal ion binding
GO:0004325 - ferrochelatase activity
biological_process GO:0006779 - porphyrin-containing compound biosynthetic process
GO:0009416 - response to light stimulus
GO:0006783 - heme biosynthetic process
GO:0046501 - protoporphyrinogen IX metabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Yang H., et al., 1995
External database links:  
ALPHAFOLD:
 P23871
ECOCYC:
 PROTOHEME-FERROCHELAT-MONOMER
ECOLIWIKI:
 b0475
INTERPRO:
 IPR033644
INTERPRO:
 IPR033659
INTERPRO:
 IPR019772
INTERPRO:
 IPR001015
MODBASE:
 P23871
PANTHER:
 PTHR11108
PFAM:
 PF00762
PRIDE:
 P23871
PRODB:
 PRO_000022876
PROSITE:
 PS00534
REFSEQ:
 NP_415008
SMR:
 P23871
UNIPROT:
 P23871


Operon      
Name: hemH         
Operon arrangement:
Transcription unit        Promoter
hemH


Transcriptional Regulation      
Display Regulation             
Activated by: OxyR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_642 499566 forward nd [RS-EPT-CBR] [2]
  promoter TSS_643 499570 forward nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Yang H., Inokuchi H., Adler J., 1995, Phototaxis away from blue light by an Escherichia coli mutant accumulating protoporphyrin IX., Proc Natl Acad Sci U S A 92(16):7332-6

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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