RegulonDB RegulonDB 11.2: Gene Form
   

hisH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hisC hisB hisF hisA hisH hisI hisD TSS_2362 TSS_2362 TSS_2361 TSS_2361 TSS_2360 TSS_2360 TSS_2359 TSS_2359 TSS_2358 TSS_2358 TSS_2357 TSS_2357 TSS_2356 TSS_2356 TSS_2355 TSS_2355 TSS_2354 TSS_2354 TSS_2353 TSS_2353 TSS_2352 TSS_2352 hisBp hisBp TSS_2351 (cluster) TSS_2351 (cluster)

Gene      
Name: hisH    Texpresso search in the literature
Synonym(s): ECK2018, EG10450, b2023
Genome position(nucleotides): 2094535 --> 2095125
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.68
External database links:  
ASAP:
 ABE-0006722
CGSC:
 629
ECHOBASE:
 EB0445
ECOLIHUB:
 hisH
OU-MICROARRAY:
 b2023
STRING:
 511145.b2023
COLOMBOS: hisH


Product      
Name: imidazole glycerol phosphate synthase subunit HisH
Synonym(s): HisH, hisH enzyme
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 21.653
Isoelectric point: 5.245
Motif(s):
 
Type Positions Sequence Comment
2 -> 196 NVVILDTGCANLNSVKSAIARHGYEPKVSRDPDVVLLADKLFLPGVGTAQAAMDQVRERELFDLIKACTQPVLGICLGMQLLGRRSEESNGVDLLGIIDEDVPKMTDFGLPLPHMGWNRVYPQAGNRLFQGIEDGAYFYFVHSYAMPVNPWTIAQCNYGEPFTAAVQKDNFYGVQFHPERSGAAGAKLLKNFLEM UniProt: Glutamine amidotransferase type-1.
6 -> 194 LDTGCANLNSVKSAIARHGYEPKVSRDPDVVLLADKLFLPGVGTAQAAMDQVRERELFDLIKACTQPVLGICLGMQLLGRRSEESNGVDLLGIIDEDVPKMTDFGLPLPHMGWNRVYPQAGNRLFQGIEDGAYFYFVHSYAMPVNPWTIAQCNYGEPFTAAVQKDNFYGVQFHPERSGAAGAKLLKNFL

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.16 - histidine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0009382 - imidazoleglycerol-phosphate synthase complex
molecular_function GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0016829 - lyase activity
GO:0016763 - pentosyltransferase activity
GO:0000107 - imidazoleglycerol-phosphate synthase activity
GO:0004359 - glutaminase activity
biological_process GO:0000105 - histidine biosynthetic process
GO:0006541 - glutamine metabolic process
GO:0008652 - cellular amino acid biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P60595
ECOCYC:
 GLUTAMIDOTRANS-MONOMER
ECOLIWIKI:
 b2023
INTERPRO:
 IPR017926
INTERPRO:
 IPR010139
INTERPRO:
 IPR029062
MODBASE:
 P60595
PANTHER:
 PTHR42701
PFAM:
 PF00117
PRIDE:
 P60595
PRODB:
 PRO_000022897
PROSITE:
 PS51273
REFSEQ:
 NP_416527
SMR:
 P60595
UNIPROT:
 P60595


Operon      
Name: hisLGDCBHAFI         
Operon arrangement:
Transcription unit        Promoter
hisL
hisLGDCBHAFI
hisBHAFI


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2351 (cluster) 2093335 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2352 2093364 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2353 2093383 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2354 2093403 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2355 2093486 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2356 2094307 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2357 2094355 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2358 2095145 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2359 2096338 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2360 2096542 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2361 2096572 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2362 2096612 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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