RegulonDB RegulonDB 10.9: Gene Form
   

hisP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

rpnB hisP hisM hisQ anti-anti-terminator anti-terminator terminator yfcIp7 yfcIp7 yfcIp8 yfcIp8

Gene      
Name: hisP    Texpresso search in the literature
Synonym(s): ECK2300, EG10452, b2306
Genome position(nucleotides): 2423736 <-- 2424509 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.94
External database links:  
ASAP:
 ABE-0007610
CGSC:
 626
ECHOBASE:
 EB0447
ECOLIHUB:
 hisP
OU-MICROARRAY:
 b2306
STRING:
 511145.b2306
COLOMBOS: hisP


Product      
Name: lysine/arginine/ornithine ABC transporter / histidine ABC transporter, ATP binding subunit
Synonym(s): HisP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 28.653
Isoelectric point: 8.492
Motif(s):
 
Type Positions Sequence
153 -> 156 LSGG
6 -> 252 LNVIDLHKRYGEHEVLKGVSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGQTINLVRDKDGQLKVADKNQLRLLRTRLTMVFQHFNLWSHMTVLENVMEAPIQVLGLSKQEARERAVKYLAKVGIDERAQGKYPVHLSGGQQQRVSIARALAMEPEVLLFDEPTSALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARHVSTHVIFLHQGKIEEEGAPEQLFGNPQSPRLQRFL
17 -> 17 E
38 -> 45 GSSGSGKS
173 -> 180 VLLFDEPT

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
molecular_function GO:0097627 - high-affinity L-ornithine transmembrane transporter activity
GO:0005292 - high-affinity lysine transmembrane transporter activity
GO:0005289 - high-affinity arginine transmembrane transporter activity
GO:0016887 - ATPase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0015424 - ATPase-coupled amino acid transmembrane transporter activity
GO:0005291 - high-affinity L-histidine transmembrane transporter activity
biological_process GO:0097639 - L-lysine import across plasma membrane
GO:0097638 - L-arginine import across plasma membrane
GO:0097640 - L-ornithine import across plasma membrane
GO:0006865 - amino acid transport
GO:0015817 - histidine transport
GO:0003333 - amino acid transmembrane transport
GO:0089709 - L-histidine transmembrane transport
GO:1903810 - L-histidine import across plasma membrane
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 HISP-MONOMER
ECOLIWIKI:
 b2306
INTERPRO:
 IPR003593
INTERPRO:
 IPR030679
INTERPRO:
 IPR027417
INTERPRO:
 IPR017871
INTERPRO:
 IPR003439
MODBASE:
 P07109
PFAM:
 PF00005
PRIDE:
 P07109
PRODB:
 PRO_000022901
PROSITE:
 PS50893
PROSITE:
 PS00211
REFSEQ:
 NP_416809
SMART:
 SM00382
SMR:
 P07109
SWISSMODEL:
 P07109
UNIPROT:
 P07109


Operon      
Name: argT-hisJQMP         
Operon arrangement:
Transcription unit        Promoter
hisJQMP
argT-hisJQMP


Transcriptional Regulation      
Display Regulation             
Activated by: H-NS, NtrC
Repressed by: ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yfcIp8 2423614 reverse Similarity to the consensus
Read more > 		[ICWHO] [1]
  promoter yfcIp7 2423712 reverse Similarity to the consensus
Read more > 		[ICWHO] [1]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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