RegulonDB

RegulonDB RegulonDB 11.1: Gene Form

hisP gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	hisP
Synonym(s):	ECK2300, EG10452, b2306
Genome position(nucleotides):	2423736 <-- 2424509
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.94
External database links:

ASAP:	ABE-0007610
CGSC:	626
ECHOBASE:	EB0447
ECOLIHUB:	hisP
OU-MICROARRAY:	b2306
STRING:	511145.b2306
COLOMBOS:	hisP

Product

Name:

lysine/arginine/ornithine ABC transporter / histidine ABC transporter, ATP binding subunit

Synonym(s):

HisP

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

28.653

Isoelectric point:

8.492

Motif(s):

Type	Positions	Sequence	Comment
	6 -> 252	LNVIDLHKRYGEHEVLKGVSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGQTINLVRDKDGQLKVADKNQLRLLRTRLTMVFQHFNLWSHMTVLENVMEAPIQVLGLSKQEARERAVKYLAKVGIDERAQGKYPVHLSGGQQQRVSIARALAMEPEVLLFDEPTSALDPELVGEVLRIMQQLAEEGKTMVVVTHEMGFARHVSTHVIFLHQGKIEEEGAPEQLFGNPQSPRLQRFL	UniProt: ABC transporter.
	17 -> 17	E	UniProt: In Ref. 5; AA sequence..
	21 -> 181	LKGVSLQANAGDVISIIGSSGSGKSTFLRCINFLEKPSEGSIVVNGQTINLVRDKDGQLKVADKNQLRLLRTRLTMVFQHFNLWSHMTVLENVMEAPIQVLGLSKQEARERAVKYLAKVGIDERAQGKYPVHLSGGQQQRVSIARALAMEPEVLLFDEPTS
	38 -> 45	GSSGSGKS	UniProt: ATP.
	153 -> 156	LSGG

Classification:

Multifun Terms (GenProtEC)
		5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0043190 - ATP-binding cassette (ABC) transporter complex GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
	molecular_function	GO:0097627 - high-affinity L-ornithine transmembrane transporter activity GO:0005292 - high-affinity lysine transmembrane transporter activity GO:0005289 - high-affinity L-arginine transmembrane transporter activity GO:0000166 - nucleotide binding GO:0005524 - ATP binding GO:0015424 - ABC-type amino acid transporter activity GO:0005291 - high-affinity L-histidine transmembrane transporter activity
	biological_process	GO:0097639 - L-lysine import across plasma membrane GO:0097638 - L-arginine import across plasma membrane GO:0097640 - L-ornithine import across plasma membrane GO:0006865 - amino acid transport GO:0003333 - amino acid transmembrane transport GO:0089718 - amino acid import across plasma membrane GO:0089709 - L-histidine transmembrane transport GO:1903810 - L-histidine import across plasma membrane

Note(s):

Note(s): ...[more].

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

SWISSMODEL:

UNIPROT:

Operon

Name:

argT-hisJQMP

Operon arrangement:

Transcription unit	Promoter
hisJQMP	hisJp
argT-hisJQMP	argTp

Transcriptional Regulation
	Display Regulation
Activated by:	H-NS, NtrC
Repressed by:	ArgR

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	yfcIp8	2423614		reverse	nd	[COMP-AINF]	[1]
	promoter	yfcIp7	2423712		reverse	nd	[COMP-AINF]	[1]

Evidence
[COMP-AINF] Inferred computationally without human oversight

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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