RegulonDB RegulonDB 10.9: Gene Form
   

lpxL gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

mdtG trhO lpxL b1052 anti-anti-terminator anti-terminator terminator yceAp yceAp lpxLp lpxLp TSS_1332 TSS_1332

Gene      
Name: lpxL    Texpresso search in the literature
Synonym(s): ECK1039, EG10464, b1054, htrB, waaM
Genome position(nucleotides): 1115662 <-- 1116582 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.99
External database links:  
ASAP:
ABE-0003574
CGSC:
31878
ECHOBASE:
EB0459
ECOLIHUB:
lpxL
OU-MICROARRAY:
b1054
STRING:
511145.b1054
COLOMBOS: lpxL


Product      
Name: lauroyl acyltransferase
Synonym(s): HtrB, LpxL, WaaM
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 35.407
Isoelectric point: 10.306
Motif(s):
 
Type Positions Sequence
5 -> 297 PKFSTALLHPRYWLTWLGIGVLWLVVQLPYPVIYRLGCGLGKLALRFMKRRAKIVHRNLELCFPEMSEQERRKMVVKNFESVGMGLMETGMAWFWPDRRIARWTEVIGMEHIRDVQAQKRGILLVGIHFLTLELGARQFGMQEPGIGVYRPNDNPLIDWLQTWGRLRSNKSMLDRKDLKGMIKALKKGEVVWYAPDHDYGPRSSVFVPLFAVEQAATTTGTWMLARMSGACLVPFVPRRKPDGKGYQLIMLPPECSPPLDDAETTAAWMNKVVEKCIMMAPEQYMWLHRRFKT
200 -> 200 D
169 -> 169 R
238 -> 238 P
17 -> 37 WLTWLGIGVLWLVVQLPYPVI

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.3 - lipopolysaccharide --> 1.6.3.3 - lipid A
  6 - cell structure --> 6.1 - membrane
  6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016740 - transferase activity
GO:0016746 - transferase activity, transferring acyl groups
GO:0008913 - lauroyltransferase activity
biological_process GO:0006950 - response to stress
GO:0009103 - lipopolysaccharide biosynthetic process
GO:0009245 - lipid A biosynthetic process
GO:0036104 - Kdo2-lipid A biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
LAUROYLACYLTRAN-MONOMER
ECOLIWIKI:
b1054
INTERPRO:
IPR011920
INTERPRO:
IPR004960
MODBASE:
P0ACV0
PANTHER:
PTHR30606
PFAM:
PF03279
PRIDE:
P0ACV0
PRODB:
PRO_000022938
REFSEQ:
NP_415572
SMR:
P0ACV0
UNIPROT:
P0ACV0


Operon      
Name: lpxL         
Operon arrangement:
Transcription unit        Promoter
lpxL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1332 1115544 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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