RegulonDB

Gene
Name:	hypC
Synonym(s):	ECK2723, EG10485, b2728
Genome position(nucleotides):	2851864 --> 2852136 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	55.31
External database links:

ASAP:	ABE-0008962
CGSC:	33113
ECHOBASE:	EB0480
ECOLIHUB:	hypC
OU-MICROARRAY:	b2728
STRING:	511145.b2728
COLOMBOS:	hypC

Shine dalgarno
Sequence:	tgaactggctGGAGACacagcgATG

Product

Name:

hydrogenase 3 maturation protein HypC

Synonym(s):

HypC, HypC, protein involved in hydrogenase 3 maturation

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

9.732

Isoelectric point:

3.961

Motif(s):

Type	Positions	Sequence
	2 -> 2	C
	6 -> 6	P
	1 -> 71	MCIGVPGQIRTIDGNQAKVDVCGIQRDVDLTLVGSCDENGQPRVGQWVLVHVGFAMSVINEAEARDTLDAL
	51 -> 51	H

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.7 - anaerobic respiration
		2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0005515 - protein binding GO:0005506 - iron ion binding GO:0042802 - identical protein binding GO:1902670 - carbon dioxide binding
	biological_process	GO:0051604 - protein maturation

Note(s):

Note(s): ...[more].

Evidence:

[APPH] Assay of protein purified to homogeneity

Reference(s):

[1] Drapal N., et al., 1998
[2] Hartwig S., et al., 2015

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

PANTHER:

PDB:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

hypABCDE-fhlA

Operon arrangement:

Transcription unit	Promoter
hypABCDE	hypAp
hypABCDE-fhlA	hypAp
hypBCDE	hypBp
hypBCDE-fhlA	hypBp

Transcriptional Regulation
	Display Regulation
Activated by:	FhlA, FNR, IHF
Repressed by:	NsrR

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Drapal N., Bock A., 1998, Interaction of the hydrogenase accessory protein HypC with HycE, the large subunit of Escherichia coli hydrogenase 3 during enzyme maturation., Biochemistry 37(9):2941-8
[2] Hartwig S., Thomas C., Krumova N., Quitzke V., Turkowsky D., Jehmlich N., Adrian L., Sawers RG., 2015, Heterologous complementation studies in Escherichia coli with the Hyp accessory protein machinery from Chloroflexi provide insight into [NiFe]-hydrogenase large subunit recognition by the HypC protein family., Microbiology 161(11):2204-19