RegulonDB RegulonDB 11.1: Gene Form
   

ilvH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ilvI cra ilvH fruL terminator anti-terminator anti-anti-terminator TSS_153 TSS_153 fruRp8 fruRp8 TSS_152 TSS_152 TSS_151 TSS_151 TSS_150 TSS_150

Gene      
Name: ilvH    Texpresso search in the literature
Synonym(s): ECK0080, EG10499, b0078, brnP
Genome position(nucleotides): 87357 --> 87848
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.2
External database links:  
ASAP:
 ABE-0000294
CGSC:
 602
ECHOBASE:
 EB0494
ECOLIHUB:
 ilvH
OU-MICROARRAY:
 b0078
STRING:
 511145.b0078
COLOMBOS: ilvH


Product      
Name: acetolactate synthase / acetohydroxybutanoate synthase, regulatory subunit
Synonym(s): BrnP, IlvH
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 17.977
Isoelectric point: 8.946
Motif(s):
 
Type Positions Sequence Comment
4 -> 78 ILSVLLENESGALSRVIGLFSQRGYNIESLTVAPTDDPTLSRMTIQTVGDEKVLEQIEKQLHKLVDVLRVSELGQ UniProt: ACT.
12 -> 73 ESGALSRVIGLFSQRGYNIESLTVAPTDDPTLSRMTIQTVGDEKVLEQIEKQLHKLVDVLRV
84 -> 158 REIMLVKIQASGYGRDEVKRNTEIFRGQIIDVTPSLYTVQLAGTSGKLDAFLASIRDVAKIVEVARSGVVGLSRG
132 -> 132 D UniProt: In Ref. 1, 2 and 5..
159 -> 163 DKIMR UniProt: In Ref. 1; CAA25756..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.18 - isoleucine/valine
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0005948 - acetolactate synthase complex
molecular_function GO:1990610 - acetolactate synthase regulator activity
GO:0016740 - transferase activity
GO:0003984 - acetolactate synthase activity
biological_process GO:0008652 - cellular amino acid biosynthetic process
GO:0009082 - branched-chain amino acid biosynthetic process
GO:0009099 - valine biosynthetic process
GO:0050790 - regulation of catalytic activity
GO:0009097 - isoleucine biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P00894
DIP:
 DIP-10024N
ECOCYC:
 ACETOLACTSYNIII-HCHAIN-MONOMER
ECOLIWIKI:
 b0078
INTERPRO:
 IPR027271
INTERPRO:
 IPR039557
INTERPRO:
 IPR019455
INTERPRO:
 IPR004789
INTERPRO:
 IPR002912
MODBASE:
 P00894
PANTHER:
 PTHR30239
PDB:
 2F1F
PFAM:
 PF10369
PFAM:
 PF13710
PRIDE:
 P00894
PRODB:
 PRO_000023007
PROSITE:
 PS51671
REFSEQ:
 NP_414620
SMR:
 P00894
SWISSMODEL:
 P00894
UNIPROT:
 P00894


Operon      
Name: ilvIH         
Operon arrangement:
Transcription unit        Promoter
ilvIH
ilvIH
ilvIH
ilvIH


Transcriptional Regulation      
Display Regulation             
Activated by: Lrp
Repressed by: H-NS, Lrp


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_150 86542 forward nd [RS-EPT-CBR] [1]
  promoter TSS_151 86559 forward nd [RS-EPT-CBR] [1]
  promoter TSS_152 87478 forward nd [RS-EPT-CBR] [1]
  promoter TSS_153 87969 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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