RegulonDB RegulonDB 10.9: Gene Form
   

kdpB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

kdpB kdpA kdpC kdpD

Gene      
Name: kdpB    Texpresso search in the literature
Synonym(s): ECK0685, EG10514, b0697, kac
Genome position(nucleotides): 724988 <-- 727036 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
56.22
External database links:  
ASAP:
ABE-0002376
CGSC:
587
ECHOBASE:
EB0509
ECOLIHUB:
kdpB
OU-MICROARRAY:
b0697
STRING:
511145.b0697
COLOMBOS: kdpB


Product      
Name: K+ transporting P-type ATPase subunit KdpB
Synonym(s): Kac, KdpB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 72.199
Isoelectric point: 7.819
Motif(s):
 
Type Positions Sequence
62 -> 82 ALFSAAISGWLWITVLFANFA
119 -> 282 DKVPADQLRKGDIVLVEAGDIIPCDGEVIEGGASVDESAITGESAPVIRESGGDFASVTGGTRILSDWLVIECSVNPGETFLDRMIAMVEGAQRRKTPNEIALTILLIALTIVFLLATATLWPFSAWGGNAVSVTVLVALLVCLIPTTIGGLLSAIGVAGMSRM
377 -> 384 FTAQSRMS
395 -> 395 K
588 -> 608 FAIIPAAFAATYPQLNALNIM

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.3 - The P-type ATPase (P-ATPase) Superfamily
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0031004 - potassium ion-transporting ATPase complex
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0046872 - metal ion binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0008556 - potassium transmembrane transporter activity, phosphorylative mechanism
GO:0000287 - magnesium ion binding
biological_process GO:0006811 - ion transport
GO:0006813 - potassium ion transport
GO:0071805 - potassium ion transmembrane transport
GO:0098655 - cation transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Bramkamp M., et al., 2004
[2] Bramkamp M., et al., 2004
[3] Haupt M., et al., 2004
[4] Haupt M., et al., 2006
[5] Kuhlbrandt W. 2004
External database links:  
ECOCYC:
KDPB-MONOMER
ECOLIWIKI:
b0697
INTERPRO:
IPR023214
INTERPRO:
IPR018303
INTERPRO:
IPR008250
INTERPRO:
IPR006391
INTERPRO:
IPR023299
INTERPRO:
IPR023298
INTERPRO:
IPR001757
INTERPRO:
IPR036412
MINT:
P03960
MODBASE:
P03960
PANTHER:
PTHR43743
PDB:
6HRB
PDB:
6HRA
PDB:
5MRW
PDB:
2A29
PDB:
2A00
PDB:
1U7Q
PDB:
1SVJ
PFAM:
PF00122
PFAM:
PF00702
PRIDE:
P03960
PRODB:
PRO_000023051
PROSITE:
PS00154
REFSEQ:
NP_415225
SMR:
P03960
UNIPROT:
P03960


Operon      
Name: kdpFABC         
Operon arrangement:
Transcription unit        Promoter
kdpFABC


Transcriptional Regulation      
Display Regulation             
Activated by: KdpE


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Bramkamp M., Altendorf K., 2004, Functional modules of KdpB, the catalytic subunit of the Kdp-ATPase from Escherichia coli., Biochemistry 43(38):12289-96

 [2] Bramkamp M., Gassel M., Altendorf K., 2004, FITC binding site and p-nitrophenyl phosphatase activity of the Kdp-ATPase of Escherichia coli., Biochemistry 43(15):4559-67

 [3] Haupt M., Bramkamp M., Coles M., Altendorf K., Kessler H., 2004, Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes., J Mol Biol 342(5):1547-58

 [4] Haupt M., Bramkamp M., Heller M., Coles M., Deckers-Hebestreit G., Herkenhoff-Hesselmann B., Altendorf K., Kessler H., 2006, The holo-form of the nucleotide binding domain of the KdpFABC complex from Escherichia coli reveals a new binding mode., J Biol Chem 281(14):9641-9

 [5] Kuhlbrandt W., 2004, Biology, structure and mechanism of P-type ATPases., Nat Rev Mol Cell Biol 5(4):282-95


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