RegulonDB

Gene
Name:	kdsA
Synonym(s):	ECK1203, EG10518, b1215
Genome position(nucleotides):	1268165 --> 1269019
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.58
External database links:

ASAP:	ABE-0004077
CGSC:	17671
ECHOBASE:	EB0513
ECOLIHUB:	kdsA
OU-MICROARRAY:	b1215
STRING:	511145.b1215
COLOMBOS:	kdsA

Shine dalgarno
Sequence:	cattttactcAAGATTaaggcgatcctATG

Product

Name:

3-deoxy-D-manno-octulosonate 8-phosphate synthase

Synonym(s):

KdsA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

30.833

Isoelectric point:

6.795

Motif(s):

Type	Positions	Sequence	Comment
	10 -> 274	DINVANDLPFVLFGGMNVLESRDLAMRICEHYVTVTQKLGIPYVFKASFDKANRSSIHSYRGPGLEEGMKIFQELKQTFGVKIITDVHEPSQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFVSPGQMGNIVDKFKEGGNEKVILCDRGANFGYDNLVVDMLGFSIMKKVSGNSPVIFDVTHALQCRDPFGAASGGRRAQVAELARAGMAVGLAGLFIEAHPDPEHAKCDGPSALPLAKLEPFLKQMKAIDDLV
	22 -> 22	F	UniProt: In Ref. 1; CAA29067..

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.3 - lipopolysaccharide --> 1.6.3.2 - core region
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
	molecular_function	GO:0003824 - catalytic activity GO:0016740 - transferase activity GO:0008676 - 3-deoxy-8-phosphooctulonate synthase activity GO:0042802 - identical protein binding
	biological_process	GO:0009058 - biosynthetic process GO:0009103 - lipopolysaccharide biosynthetic process GO:0046364 - monosaccharide biosynthetic process GO:0019294 - keto-3-deoxy-D-manno-octulosonic acid biosynthetic process

Note(s):

Note(s): ...[more].

Reference(s):

[1] Tolbert WD., et al., 1996
[2] Wen L., et al., 2016
[3] Woisetschlager M., et al., 1986

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

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PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

ychQA-kdsA

Operon arrangement:

Transcription unit	Promoter
ychQA-kdsA	ychQp
kdsA	kdsAp

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Tolbert WD., Moll JR., Bauerle R., Kretsinger RH., 1996, Crystallization and preliminary crystallographic studies of 3-deoxy-D-manno-octulosonate-8-phosphate synthase from Escherichia coli., Proteins 24(3):407-8
[2] Wen L., Zheng Y., Li T., Wang PG., 2016, Enzymatic synthesis of 3-deoxy-d-manno-octulosonic acid (KDO) and its application for LPS assembly., Bioorg Med Chem Lett 26(12):2825-2828
[3] Woisetschlager M., Hogenauer G., 1986, Cloning and characterization of the gene encoding 3-deoxy-D-manno-octulosonate 8-phosphate synthetase from Escherichia coli., J Bacteriol 168(1):437-9