RegulonDB RegulonDB 10.9: Gene Form
   

livM gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

livM livK livH livG livF TSS_4058 TSS_4058

Gene      
Name: livM    Texpresso search in the literature
Synonym(s): ECK3440, EG10541, b3456
Genome position(nucleotides): 3594203 <-- 3595480 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
56.57
External database links:  
ASAP:
ABE-0011287
CGSC:
18190
ECHOBASE:
EB0536
ECOLIHUB:
livM
OU-MICROARRAY:
b3456
STRING:
511145.b3456
COLOMBOS: livM


Shine dalgarno      
Sequence: ctgggtcgccCGGAGGtagagaaagTAT


Product      
Name: branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM
Synonym(s): LivM
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 46.269
Isoelectric point: 10.087
Motif(s):
 
Type Positions Sequence
112 -> 398 VDIATLTMIYIILGLGLNVVVGLSGLLVLGYGGFYAIGAYTFALLNHYYGLGFWTCLPIAGLMAAAAGFLLGFPVLRLRGDYLAIVTLGFGEIVRILLLNNTEITGGPNGISQIPKPTLFGLEFSRTAREGGWDTFSNFFGLKYDPSDRVIFLYLVALLLVVLSLFVINRLLRMPLGRAWEALREDEIACRSLGLSPRRIKLTAFTISAAFAGFAGTLFAARQGFVSPESFTFAESAFVLAIVVLGGMGSQFAVILAAILLVVSRELMRDFNEYSMLMLGGLMVLMM
191 -> 211 GDYLAIVTLGFGEIVRILLLN
387 -> 407 MLMLGGLMVLMMIWRPQGLLP
167 -> 187 CLPIAGLMAAAAGFLLGFPVL
260 -> 280 RVIFLYLVALLLVVLSLFVIN

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.18 - isoleucine/valine
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.19 - leucine
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0022857 - transmembrane transporter activity
GO:0015192 - L-phenylalanine transmembrane transporter activity
GO:0015658 - branched-chain amino acid transmembrane transporter activity
GO:0005304 - L-valine transmembrane transporter activity
GO:0015190 - L-leucine transmembrane transporter activity
GO:0015188 - L-isoleucine transmembrane transporter activity
biological_process GO:0006865 - amino acid transport
GO:0015803 - branched-chain amino acid transport
GO:0015823 - phenylalanine transport
GO:0055085 - transmembrane transport
GO:1903714 - isoleucine transmembrane transport
GO:1903785 - L-valine transmembrane transport
GO:0098713 - leucine import across plasma membrane
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
[2] Nazos PM., et al., 1985
External database links:  
ECOCYC:
LIVM-MONOMER
ECOLIWIKI:
b3456
INTERPRO:
IPR043428
INTERPRO:
IPR021807
INTERPRO:
IPR001851
PANTHER:
PTHR30482
PFAM:
PF11862
PFAM:
PF02653
PRIDE:
P22729
PRODB:
PRO_000023099
REFSEQ:
NP_417913
UNIPROT:
P22729


Operon      
Name: livKHMGF         
Operon arrangement:
Transcription unit        Promoter
livKHMGF
livKHMGF


Transcriptional Regulation      
Display Regulation             
Repressed by: Lrp


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4058 3596577 reverse nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Nazos PM., Mayo MM., Su TZ., Anderson JJ., Oxender DL., 1985, Identification of livG, a membrane-associated component of the branched-chain amino acid transport in Escherichia coli., J Bacteriol 163(3):1196-202

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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