RegulonDB RegulonDB 10.10: Gene Form
   

lpxA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

lpxB lpxA rnhB fabZ TSS_381 TSS_381 TSS_380 TSS_380 TSS_379 TSS_379 TSS_378 TSS_378 TSS_377 TSS_377 TSS_376 TSS_376 TSS_375 TSS_375

Gene      
Name: lpxA    Texpresso search in the literature
Synonym(s): ECK0180, EG10545, b0181
Genome position(nucleotides): 202560 --> 203348 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.11
External database links:  
ASAP:
 ABE-0000618
CGSC:
 17665
ECHOBASE:
 EB0540
ECOLIHUB:
 lpxA
OU-MICROARRAY:
 b0181
STRING:
 511145.b0181
COLOMBOS: lpxA


Product      
Name: acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase
Synonym(s): LpxA, UDP-N-acetylglucosamine acyltransferase
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 28.08
Isoelectric point: 7.146
Motif(s):
 
Type Positions Sequence
64 -> 65 QF
109 -> 143 TKVGSDNLLMINAHIAHDCTVGNRCILANNATLAG
125 -> 125 H
180 -> 261 DVPPYVIAQGNHATPFGVNIEGLKRRGFSREAITAIRNAYKLIYRSGKTLDEVKPEIAELAETYPEVKAFTDFFARSTRGLI
189 -> 189 G

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.3 - lipopolysaccharide --> 1.6.3.3 - lipid A
  6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016740 - transferase activity
GO:0016746 - acyltransferase activity
GO:0008780 - acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
GO:0042802 - identical protein binding
biological_process GO:0006629 - lipid metabolic process
GO:0008610 - lipid biosynthetic process
GO:0009245 - lipid A biosynthetic process
External database links:  
DIP:
 DIP-48043N
ECOCYC:
 UDPNACETYLGLUCOSAMACYLTRANS-MONOMER
ECOLIWIKI:
 b0181
INTERPRO:
 IPR001451
INTERPRO:
 IPR037157
INTERPRO:
 IPR010137
INTERPRO:
 IPR011004
INTERPRO:
 IPR018357
INTERPRO:
 IPR029098
MODBASE:
 P0A722
PANTHER:
 PTHR43480
PDB:
 2JF2
PDB:
 6HY2
PDB:
 4J09
PDB:
 2QIV
PDB:
 2QIA
PDB:
 2JF3
PDB:
 1LXA
PDB:
 2AQ9
PFAM:
 PF00132
PFAM:
 PF13720
PRIDE:
 P0A722
PRODB:
 PRO_000023120
PROSITE:
 PS00101
REFSEQ:
 NP_414723
SMR:
 P0A722
UNIPROT:
 P0A722


Operon      
Name: bamA-skp-lpxD-fabZ-lpxAB-rnhB-dnaE         
Operon arrangement:
Transcription unit        Promoter
bamA-hlpA-lpxD-fabZ-lpxAB-rnhB-dnaE
bamA
hlpA-lpxD-fabZ-lpxA
lpxD
fabZ


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR, GadE


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_375 202110 forward nd [RS-EPT-CBR] [1]
  promoter TSS_376 202370 forward nd [RS-EPT-CBR] [1]
  promoter TSS_377 202372 forward nd [RS-EPT-CBR] [1]
  promoter TSS_378 202585 forward nd [RS-EPT-CBR] [1]
  promoter TSS_379 202645 forward nd [RS-EPT-CBR] [1]
  promoter TSS_380 204501 forward nd [RS-EPT-CBR] [1]
  promoter TSS_381 204507 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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