RegulonDB RegulonDB 11.1: Gene Form
   

mazG gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pyrG mazG mazF Cra Cra anti-anti-terminator anti-terminator terminator mazGp4 mazGp4 pyrGp1 pyrGp1 TSS_3083 (cluster) TSS_3083 (cluster) pyrGp2 pyrGp2 TSS_3082 (cluster) TSS_3082 (cluster) pyrGp pyrGp TSS_3081 TSS_3081 TSS_3080 TSS_3080 TSS_3079 TSS_3079 TSS_3078 TSS_3078 TSS_3077 TSS_3077 TSS_3076 TSS_3076 enop3 enop3 enop2 enop2 enop1 enop1 TSS_3075 TSS_3075 TSS_3074 (cluster) TSS_3074 (cluster) enop7 enop7 enop5 enop5

Gene      
Name: mazG    Texpresso search in the literature
Synonym(s): ECK2775, EG10572, b2781
Genome position(nucleotides): 2909894 <-- 2910685
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 50.76
External database links:  
ASAP:
 ABE-0009117
ECHOBASE:
 EB0567
ECOLIHUB:
 mazG
OU-MICROARRAY:
 b2781
STRING:
 511145.b2781
COLOMBOS: mazG


Product      
Name: nucleoside triphosphate pyrophosphohydrolase
Synonym(s): MazG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 30.412
Isoelectric point: 4.393
Motif(s):
 
Type Positions Sequence Comment
27 -> 100 QTFATIAPYTLEETYEVLDAIAREDFDDLRGELGDLLFQVVFYAQMAQEEGRFDFNDICAAISDKLERRHPHVF
95 -> 95 R UniProt: Does not affect nucleotide pyrophosphohydrolysis activity..
119 -> 119 K UniProt: Does not affect the nucleotide pyrophosphohydrolysis activity..
168 -> 168 K UniProt: Does not affect nucleotide pyrophosphohydrolysis activity..
169 -> 227 VYEEIDEVMYEARQAVVDQAKLEEEMGDLLFATVNLARHLGTKAEIALQKANEKFERRF

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.3 - starvation
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0047429 - nucleoside-triphosphate diphosphatase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0047693 - ATP diphosphatase activity
biological_process GO:0009267 - cellular response to starvation
GO:0006203 - dGTP catabolic process
GO:0046081 - dUTP catabolic process
GO:0046047 - TTP catabolic process
GO:0046052 - UTP catabolic process
GO:0046061 - dATP catabolic process
GO:0046076 - dTTP catabolic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P0AEY3
DIP:
 DIP-48054N
ECOCYC:
 EG10572-MONOMER
ECOLIWIKI:
 b2781
INTERPRO:
 IPR004518
INTERPRO:
 IPR011551
PANTHER:
 PTHR30522
PDB:
 3CRC
PDB:
 3CRA
PFAM:
 PF03819
PRIDE:
 P0AEY3
PRODB:
 PRO_000023168
REFSEQ:
 NP_417261
SMR:
 P0AEY3
UNIPROT:
 P0AEY3


Operon      
Name: relA-mazEFG         
Operon arrangement:
Transcription unit        Promoter
mazEFG
mazEFG
relA
relA-mazEF
relA-mazEF
relA


Transcriptional Regulation      
Display Regulation             
Activated by: Fis
Repressed by: MazE, MazE-MazF


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3074 (cluster) 2908226 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3075 2908550 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3076 2908879 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3077 2908881 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3078 2909694 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3079 2909704 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3080 2909706 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3081 2909711 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3082 (cluster) 2909716 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_3083 (cluster) 2909795 reverse nd [RS-EPT-CBR] [1]
  promoter mazGp4 2910860 reverse nd [COMP-AINF] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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