RegulonDB RegulonDB 10.8: Gene Form
   

groS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

groL yjeH groS anti-anti-terminator terminator anti-terminator anti-anti-terminator terminator TSS_4958 TSS_4958 TSS_4957 TSS_4957 groLp3 groLp3 TSS_4956 TSS_4956 TSS_4955 TSS_4955 groLp2 groLp2 groLp1 groLp1 TSS_4954 TSS_4954 TSS_4953 TSS_4953 TSS_4952 TSS_4952 TSS_4951 TSS_4951 groSp groSp TSS_4949 (cluster) TSS_4949 (cluster)

Gene      
Name: groS    Texpresso search in the literature
Synonym(s): ECK4136, EG10600, b4142, groES, mopB
Genome position(nucleotides): 4370688 --> 4370981 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
48.64
External database links:  
ASAP:
ABE-0013566
CGSC:
493
ECHOBASE:
EB0595
OU-MICROARRAY:
b4142
PortEco:
groS
STRING:
511145.b4142
COLOMBOS: groS


Product      
Name: cochaperonin GroES
Synonym(s): GroES, GroS, MopB, cpn10
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 10.387
Isoelectric point: 4.889
Motif(s):
 
Type Positions Sequence
89 -> 89 S
2 -> 95 NIRPLHDRVIVKRKEVETKSAGGIVLTGSAAAKSTRGEVLAVGNGRILENGEVKPLDVKVGDIVIFNDGYGVKSEKIDNEEVLIMSESDILAIV

 

Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.4 - chaperoning, repair (refolding)
  5 - cell processes --> 5.1 - cell division
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:1990220 - GroEL-GroES complex
molecular_function GO:0005515 - protein binding
GO:0046872 - metal ion binding
GO:0051082 - unfolded protein binding
GO:0005524 - ATP binding
GO:0042802 - identical protein binding
GO:0051087 - chaperone binding
biological_process GO:0051301 - cell division
GO:0006457 - protein folding
GO:0007049 - cell cycle
GO:0009408 - response to heat
GO:0051085 - chaperone cofactor-dependent protein refolding
GO:0019068 - virion assembly
Note(s): Note(s): ...[more].
Reference(s): [1] Chandrasekhar GN., et al., 1986
[2] Tilly K., et al., 1981
External database links:  
DIP:
DIP-9835N
ECOCYC:
EG10600-MONOMER
ECOLIWIKI:
b4142
INTERPRO:
IPR037124
INTERPRO:
IPR018369
INTERPRO:
IPR011032
INTERPRO:
IPR020818
MINT:
P0A6F9
MODBASE:
P0A6F9
PANTHER:
PTHR10772
PDB:
3ZQ0
PDB:
3ZQ1
PDB:
5OPX
PDB:
3ZPZ
PDB:
3WVL
PDB:
2C7C
PDB:
1SX4
PDB:
1SVT
PDB:
1PF9
PDB:
1PCQ
PDB:
1GRU
PDB:
1EGS
PDB:
1AON
PDB:
2C7D
PFAM:
PF00166
PRIDE:
P0A6F9
PRINTS:
PR00297
PRODB:
PRO_000022839
PROSITE:
PS00681
REFSEQ:
NP_418566
SMART:
SM00883
SMR:
P0A6F9
UNIPROT:
P0A6F9


Operon      
Name: groSL         
Operon arrangement:
Transcription unit        Promoter
groSL
groL
groL
groL


RNA cis-regulatory element    
Attenuation: Transcriptional


Regulation by small RNA    
  Display Regulation
small RNA gcvB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4949 (cluster) 4370456 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4951 4370648 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4952 4370652 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4953 4370659 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4954 4370692 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4955 4370897 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4956 4370958 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4957 4371007 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4958 4371474 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Chandrasekhar GN., Tilly K., Woolford C., Hendrix R., Georgopoulos C., 1986, Purification and properties of the groES morphogenetic protein of Escherichia coli., J Biol Chem 261(26):12414-9

 [2] Tilly K., McKittrick N., Georgopoulos C., Murialdo H., 1981, Studies on Escherichia coli mutants which block bacteriophage morphogenesis., Prog Clin Biol Res 64:35-45

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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