RegulonDB RegulonDB 10.9: Gene Form
   

mrp gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

metG mrp yehE anti-anti-terminator anti-terminator terminator terminator metGp metGp TSS_2441 TSS_2441 mrpp mrpp TSS_2440 (cluster) TSS_2440 (cluster) TSS_2439 (cluster) TSS_2439 (cluster) TSS_2438 TSS_2438 mrpp7 mrpp7 mrpp2 mrpp2 metGp2 metGp2 yehEp1 yehEp1 yehEp8 yehEp8 yehEp7 yehEp7 TSS_2437 TSS_2437

Gene      
Name: mrp    Texpresso search in the literature
Synonym(s): ECK2106, EG10611, b2113
Genome position(nucleotides): 2193059 <-- 2194168 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.96
External database links:  
ASAP:
ABE-0006987
ECHOBASE:
EB0606
ECOLIHUB:
mrp
MIM:
252010
OU-MICROARRAY:
b2113
STRING:
511145.b2113
COLOMBOS: mrp


Product      
Name: P-loop NTPase family protein Mrp
Synonym(s): Mrp
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 39.938
Isoelectric point: 6.275
Motif(s):
 
Type Positions Sequence
106 -> 349 VKNIIAVSSGKGGVGKSSTAVNLALALAAEGAKVGILDADIYGPSIPTMLGAENQRPTSPDGTHMAPIMSHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDYLVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSVHICSNCGHHEPIFGTGGAEKLAEKYHTQLLGQMPLHISLREDLDKGTPTVISRPESEFTAIYRQLADRV
115 -> 122 GKGGVGKS

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016787 - hydrolase activity
GO:0016887 - ATPase activity
GO:0046872 - metal ion binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0051536 - iron-sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
biological_process GO:0016226 - iron-sulfur cluster assembly
Note(s): Note(s): ...[more].
Reference(s): [1] Dardel F., et al., 1991
[2] Gerard E., et al., 1998
[3] High NJ., et al., 1996
External database links:  
ECOCYC:
EG10611-MONOMER
ECOLIWIKI:
b2113
INTERPRO:
IPR033756
INTERPRO:
IPR034904
INTERPRO:
IPR027417
INTERPRO:
IPR019591
INTERPRO:
IPR000808
MODBASE:
P0AF08
PFAM:
PF10609
PRIDE:
P0AF08
PRODB:
PRO_000023292
PROSITE:
PS01215
REFSEQ:
NP_416616
UNIPROT:
P0AF08


Operon      
Name: mrp         
Operon arrangement:
Transcription unit        Promoter
mrp


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2437 2192686 forward nd [RS-EPT-CBR] [4]
  promoter yehEp7 2192880 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter yehEp8 2192901 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter yehEp1 2192909 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter mrpp2 2194175 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter mrpp7 2194180 reverse Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter TSS_2438 2194185 reverse nd [RS-EPT-CBR] [4]
  promoter TSS_2439 (cluster) 2194194 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [4]
  promoter TSS_2440 (cluster) 2194200 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [4]
  promoter TSS_2441 2194222 reverse nd [RS-EPT-CBR] [4]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Dardel F., Panvert M., Blanquet S., Fayat G., 1991, Locations of the metG and mrp genes on the physical map of Escherichia coli., J Bacteriol 173(11):3273

 [2] Gerard E., Labedan B., Forterre P., 1998, Isolation of a minD-like gene in the hyperthermophilic archaeon Pyrococcus AL585, and phylogenetic characterization of related proteins in the three domains of life., Gene 222(1):99-106

 [3] High NJ., Deadman ME., Hood DW., Moxon ER., 1996, The identification a novel gene required for lipopolysaccharide biosynthesis by Haemophilus influenzae RM7004, using transposon Tn916 mutagenesis., FEMS Microbiol Lett 145(3):325-31

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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