RegulonDB RegulonDB 11.1: Gene Form
   

phnP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

phnP phnO yjdP phnN

Gene      
Name: phnP    Texpresso search in the literature
Synonym(s): ECK4085, EG10725, b4092
Genome position(nucleotides): 4314344 <-- 4315102
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 59.29
External database links:  
ASAP:
 ABE-0013412
CGSC:
 34514
ECHOBASE:
 EB0719
ECOLIHUB:
 phnP
OU-MICROARRAY:
 b4092
STRING:
 511145.b4092
COLOMBOS: phnP


Product      
Name: 5-phospho-α-D-ribosyl 1,2-cyclic phosphate phosphodiesterase
Synonym(s): PhnP
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 27.848
Isoelectric point: 6.364
Motif(s):
 
Type Positions Sequence Comment
54 -> 54 D UniProt: Has a 1000-fold lower activity..
70 -> 223 QQFLLTHYHMDHVQGLFPLRWGVGDPIPVYGPPDEQGCDDLFKHPGLLDFSHTVEPFVVFDLQGLQVTPLPLNHSKLTFGYLLETAHSRVAWLSDTAGLPEKTLKFLRNNQPQVMVMDCSHPPRADAPRNHCDLNTVLALNQVIRSPRVILTHI
75 -> 75 T UniProt: Has 40-fold lower activity..
78 -> 78 H UniProt: Has 250-fold lower activity..
80 -> 80 D UniProt: Has 1000-fold lower activity, and has 100-fold lower affinity for manganese..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.1 - phosphorous metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0103043 - 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase activity
GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0008081 - phosphoric diester hydrolase activity
GO:0030145 - manganese ion binding
GO:0042803 - protein homodimerization activity
biological_process GO:0019700 - organic phosphonate catabolic process
External database links:  
ALPHAFOLD:
 P16692
ECOCYC:
 EG10725-MONOMER
ECOLIWIKI:
 b4092
INTERPRO:
 IPR035682
INTERPRO:
 IPR036866
INTERPRO:
 IPR017693
INTERPRO:
 IPR001279
MODBASE:
 P16692
PDB:
 3P2U
PDB:
 3G1P
PFAM:
 PF12706
PRIDE:
 P16692
PRODB:
 PRO_000023539
REFSEQ:
 NP_418516
SMR:
 P16692
UNIPROT:
 P16692


Operon      
Name: phnCDEFGHIJKLMNOP         
Operon arrangement:
Transcription unit        Promoter
phnCDEEFGHIJKLMNOP
phnLMNOP


Transcriptional Regulation      
Display Regulation             
Activated by: PhoB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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