RegulonDB RegulonDB 10.9: Gene Form
   

pldB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pldB yigL rhtB TSS_4482 (cluster) TSS_4482 (cluster) TSS_4481 TSS_4481 pldBp4 pldBp4 pldBp6 pldBp6

Gene      
Name: pldB    Texpresso search in the literature
Synonym(s): ECK3819, EG10739, b3825
Genome position(nucleotides): 4009170 --> 4010192 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.76
External database links:  
ASAP:
ABE-0012494
CGSC:
5001
ECHOBASE:
EB0732
ECOLIHUB:
pldB
OU-MICROARRAY:
b3825
STRING:
511145.b3825
COLOMBOS: pldB


Product      
Name: lysophospholipase L2
Synonym(s): PldB
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 38.978
Isoelectric point: 7.819
Motif(s):
 
Type Positions Sequence
315 -> 315 R
52 -> 312 HHDRVVVICPGRIESYVKYAELAYDLFHLGFDVLIIDHRGQGRSGRLLADPHLGHVNRFNDYVDDLAAFWQQEVQPGPWRKRYILAHSMGGAISTLFLQRHPGVCDAIALTAPMFGIVIRMPSFMARQILNWAEAHPRFRDGYAIGTGRWRALPFAINVLTHSRQRYRRNLRFYADDPTIRVGGPTYHWVRESILAGEQVLAGAGDDATPTLLLQAEEERVVDNRMHDRFCELRTAAGHPVEGGRPLVIKGAYHEILFEKD
164 -> 164 P

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0009898 - cytoplasmic side of plasma membrane
molecular_function GO:0102545 - phosphatidyl phospholipase B activity
GO:0005515 - protein binding
GO:0016787 - hydrolase activity
GO:0016747 - transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016298 - lipase activity
GO:0004622 - lysophospholipase activity
biological_process GO:0006629 - lipid metabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Albright FR., et al., 1973
[2] Hsu L., et al., 1991
[3] Karasawa K., et al., 1991
[4] Kobayashi T., et al., 1985
External database links:  
ECOCYC:
EG10739-MONOMER
ECOLIWIKI:
b3825
INTERPRO:
IPR022742
INTERPRO:
IPR029058
MODBASE:
P07000
PFAM:
PF12146
PRIDE:
P07000
REFSEQ:
YP_026266
UNIPROT:
P07000


Operon      
Name: pldB-yigL         
Operon arrangement:
Transcription unit        Promoter
pldB-yigL


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter pldBp6 4009014 forward Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter pldBp4 4009023 forward Similarity to the consensus
Read more >
[ICWHO] [5]
  promoter TSS_4481 4009086 reverse nd [RS-EPT-CBR] [6]
  promoter TSS_4482 (cluster) 4010009 forward For this promoter, there
Read more >
[RS-EPT-CBR] [6]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Albright FR., White DA., Lennarz WJ., 1973, Studies on enzymes involved in the catabolism of phospholipids in Escherichia coli., J Biol Chem 248(11):3968-77

 [2] Hsu L., Jackowski S., Rock CO., 1991, Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity., J Biol Chem 266(21):13783-8

 [3] Karasawa K., Nojima S., 1991, Lysophospholipases from Escherichia coli., Methods Enzymol 197:437-45

 [4] Kobayashi T., Kudo I., Homma H., Karasawa K., Inoue K., Ikeda H., Nojima S., 1985, Gene organization of pldA and pldB, the structural genes for detergent-resistant phospholipase A and lysophospholipase L2 of Escherichia coli., J Biochem (Tokyo) 98(4):1007-16

 [5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [6] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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