RegulonDB

Gene
Name:	pspC
Synonym(s):	ECK1301, EG10778, b1306
Genome position(nucleotides):	1369025 --> 1369384
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.28
External database links:

ASAP:	ABE-0004391
CGSC:	32015
ECHOBASE:	EB0771
ECOLIHUB:	pspC
OU-MICROARRAY:	b1306
STRING:	511145.b1306
COLOMBOS:	pspC

Product

Name:

phage shock protein C

Synonym(s):

PspC

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol,inner membrane

Molecular weight:

13.517

Isoelectric point:

6.693

Motif(s):

Type	Positions	Sequence	Comment
	8 -> 65	KKLWRIPQQGMVRGVCAGIANYFDVPVKLVRILVVLSIFFGLALFTLVAYIILSFALD
	39 -> 59	ILVVLSIFFGLALFTLVAYII	UniProt: Helical.

Classification:

Multifun Terms (GenProtEC)
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
		8 - extrachromosomal --> 8.1 - prophage genes and phage related functions
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol GO:0016020 - membrane GO:0005886 - plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0005515 - protein binding
	biological_process	GO:0010557 - positive regulation of macromolecule biosynthetic process GO:0080135 - regulation of cellular response to stress

Note(s):

Note(s): ...[more].

Evidence:

[COMP-AINF-FN-FROM-SEQ] Automated inference of function from sequence
[EXP-IMP] Inferred from mutant phenotype

Reference(s):

[1] Engl C., et al., 2011
[2] Huvet M., et al., 2011
[3] Huvet M., et al., 2009
[4] Jovanovic G., et al., 2009
[5] Jovanovic G., et al., 2014
[6] Mehner D., et al., 2012
[7] Perez-Rueda E., et al., 2004
[8] Toni T., et al., 2011
[9] Weiner L., et al., 1991

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PFAM:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

pspABCDE

Operon arrangement:

Transcription unit	Promoter
pspABCDE	pspAp
pspBCDE	pspBp
pspE	pspEp

Transcriptional Regulation
	Display Regulation
Activated by:	IHF, PspF

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Engl C., Beek AT., Bekker M., de Mattos JT., Jovanovic G., Buck M., 2011, Dissipation of proton motive force is not sufficient to induce the phage shock protein response in Escherichia coli., Curr Microbiol 62(5):1374-85
[2] Huvet M., Toni T., Sheng X., Thorne T., Jovanovic G., Engl C., Buck M., Pinney JW., Stumpf MP., 2011, The evolution of the phage shock protein response system: interplay between protein function, genomic organization, and system function., Mol Biol Evol 28(3):1141-55
[3] Huvet M., Toni T., Tan H., Jovanovic G., Engl C., Buck M., Stumpf MP., 2009, Model-based evolutionary analysis: the natural history of phage-shock stress response., Biochem Soc Trans 37(Pt 4):762-7
[4] Jovanovic G., Engl C., Buck M., 2009, Physical, functional and conditional interactions between ArcAB and phage shock proteins upon secretin-induced stress in Escherichia coli., Mol Microbiol 74(1):16-28
[5] Jovanovic G., Mehta P., McDonald C., Davidson AC., Uzdavinys P., Ying L., Buck M., 2014, The N-terminal amphipathic helices determine regulatory and effector functions of phage shock protein A (PspA) in Escherichia coli., J Mol Biol 426(7):1498-511
[6] Mehner D., Osadnik H., Lunsdorf H., Bruser T., 2012, The Tat system for membrane translocation of folded proteins recruits the membrane-stabilizing Psp machinery in Escherichia coli., J Biol Chem 287(33):27834-42
[7] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50
[8] Toni T., Jovanovic G., Huvet M., Buck M., Stumpf MP., 2011, From qualitative data to quantitative models: analysis of the phage shock protein stress response in Escherichia coli., BMC Syst Biol 5:69
[9] Weiner L., Brissette JL., Model P., 1991, Stress-induced expression of the Escherichia coli phage shock protein operon is dependent on sigma 54 and modulated by positive and negative feedback mechanisms., Genes Dev 5(10):1912-23