Gene
Name:	pyrD
Synonym(s):	ECK0936, EG10807, b0945
Genome position(nucleotides):	1004768 --> 1005778 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	46.98
External database links:

ASAP:	ABE-0003201
CGSC:	328
ECHOBASE:	EB0800
MIM:	263750
OU-MICROARRAY:	b0945
PortEco:	pyrD
STRING:	511145.b0945
COLOMBOS:	pyrD

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	ycbWp6	1005850	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.016. P-value: 6.252e-5 Read more >	[ICWHO]	[2]
promoter	TSS_1247 (cluster)	1005852	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 1005852 to 1005853, where the highest frequency is at position 1005075. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[3]
promoter	ycbWp4	1005890	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.084. P-value: 2.895e-5 Read more >	[ICWHO]	[2]

Evidence
[ICWHO] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Smyth CJ., Siegel J., Salton MR., Owen P., 1978, Immunochemical analysis of inner and outer membranes of Escherichia coli by crossed immunoelectrophoresis., J Bacteriol 133(1):306-19
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Transcriptional Regulation
	Display Regulation
Repressed by:	PurR, Fis