RegulonDB

Gene
Name:	ruvC
Synonym(s):	ECK1864, EG10925, b1863
Genome position(nucleotides):	1946855 <-- 1947376 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	55.94
External database links:

ASAP:	ABE-0006215
CGSC:	32474
ECHOBASE:	EB0918
ECOLIHUB:	ruvC
OU-MICROARRAY:	b1863
STRING:	511145.b1863
COLOMBOS:	ruvC

Product

Name:

crossover junction endodeoxyribonuclease RuvC

Synonym(s):

Holliday junction nuclease, resolution of structures, repair, RuvC

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

18.747

Isoelectric point:

9.984

Motif(s):

Type	Positions	Sequence
	4 -> 150	ILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITH
	2 -> 173	AIILGIDPGSRVTGYGVIRQVGRQLSYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRLR

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.1 - DNA related --> 2.1.3 - DNA recombination
		2 - information transfer --> 2.1 - DNA related --> 2.1.4 - DNA repair
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0048476 - Holliday junction resolvase complex
	molecular_function	GO:0003676 - nucleic acid binding GO:0004518 - nuclease activity GO:0005515 - protein binding GO:0016787 - hydrolase activity GO:0046872 - metal ion binding GO:0004520 - endodeoxyribonuclease activity GO:0008821 - crossover junction endodeoxyribonuclease activity GO:0000287 - magnesium ion binding
	biological_process	GO:0006281 - DNA repair GO:0006310 - DNA recombination GO:0006974 - cellular response to DNA damage stimulus GO:0009314 - response to radiation GO:0000725 - recombinational repair GO:0090305 - nucleic acid phosphodiester bond hydrolysis GO:0071932 - replication fork reversal

Note(s):

Note(s): ...[more].

Reference(s):

[1] Zhou R., et al., 2019

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

PANTHER:

PDB:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

nudB-yebC-ruvC

Operon arrangement:

Transcription unit	Promoter
ruvC	ruvCp
yebC-ruvC	yebCp
nudB-yebC-ruvC	nudBp

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Zhou R., Yang O., Declais AC., Jin H., Gwon GH., Freeman ADJ., Cho Y., Lilley DMJ., Ha T., 2019, Junction resolving enzymes use multivalency to keep the Holliday junction dynamic., Nat Chem Biol 15(3):269-275