RegulonDB

Gene
Name:	speF
Synonym(s):	ECK0681, EG10964, b0693
Genome position(nucleotides):	718262 <-- 720460
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	49.34
External database links:

ASAP:	ABE-0002362
CGSC:	31559
ECHOBASE:	EB0957
ECOLIHUB:	speF
OU-MICROARRAY:	b0693
STRING:	511145.b0693
COLOMBOS:	speF

Product

Name:

inducible ornithine decarboxylase

Synonym(s):

SpeF, ornithine decarboxylase, degradative

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

82.416

Isoelectric point:

5.753

Motif(s):

Type	Positions	Sequence	Comment
	4 -> 103	LKIAVSDSCPDCFTTQRECIYINESRNIDVAAIVLSLNDVTCGKLDEIDATGYGIPVFIATENQERVPAEYLPRISGVFENCESRREFYGRQLETAASHY
	109 -> 551	PPFFRALVDYVNQGNSAFDCPGHQGGEFFRRHPAGNQFVEYFGEALFRADLCNADVAMGDLLIHEGAPCIAQQHAAKVFNADKTYFVLNGTSSSNKVVLNALLTPGDLVLFDRNNHKSNHHGALLQAGATPVYLETARNPYGFIGGIDAHCFEESYLRELIAEVAPQRAKEARPFRLAVIQLGTYDGTIYNARQVVDKIGHLCDYILFDSAWVGYEQFIPMMADCSPLLLDLNENDPGILVTQSVHKQQAGFSQTSQIHKKDSHIKGQQRYVPHKRMNNAFMMHASTSPFYPLFAALNINAKMHEGVSGRNMWMDCVVNGINARKLILDNCQHIRPFVPELVDGKPWQSYETAQIAVDLRFFQFVPGEHWHSFEGYAENQYFVDPCKLLLTTPGIDARNGEYEAFGVPATILANFLRENGVVPEKCDLNSILFLLTPAEDMAK
	576 -> 705	LPSIYKQHEERYAGYTLRQLCQEMHDLYARHNVKQLQKEMFRKEHFPRVSMNPQEANYAYLRGEVELVRLPDAEGRIAAEGALPYPPGVLCVVPGEIWGGAVLRYFSALEEGINLLPGFAPELQGVYIEE

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003824 - catalytic activity GO:0016829 - lyase activity GO:0016831 - carboxy-lyase activity GO:0030170 - pyridoxal phosphate binding GO:0004586 - ornithine decarboxylase activity GO:0042803 - protein homodimerization activity
	biological_process	GO:0006520 - cellular amino acid metabolic process GO:0008295 - spermidine biosynthetic process GO:0071468 - cellular response to acidic pH GO:0033387 - putrescine biosynthetic process from ornithine

Note(s):

Note(s): ...[more].

Reference(s):

[1] Gale EF. 1940
[2] Kanjee U., et al., 2012
[3] Morris DR., et al., 1983
[4] Peng S., et al., 2014
[5] Shaibe E., et al., 1985
[6] Soksawatmaekhin W., et al., 2004
[7] Tkachenko AG., et al., 2012

External database links:

ALPHAFOLD:

P24169

DIP:

DIP-154N

ECOCYC:

ORNDECARBOXDEG-MONOMER

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Reference(s)
[1] Gale EF., 1940, The production of amines by bacteria: The decarboxylation of amino-acids by strains of Bacterium coli., Biochem J 34(3):392-413
[2] Kanjee U., Ogata K., Houry WA., 2012, Direct binding targets of the stringent response alarmone (p)ppGpp., Mol Microbiol 85(6):1029-43
[3] Morris DR., Boeker EA., 1983, Biosynthetic and biodegradative ornithine and arginine decarboxylases from Escherichia coli., Methods Enzymol 94:125-34
[4] Peng S., Stephan R., Hummerjohann J., Tasara T., 2014, Transcriptional analysis of different stress response genes in Escherichia coli strains subjected to sodium chloride and lactic acid stress., FEMS Microbiol Lett 361(2):131-7
[5] Shaibe E., Metzer E., Halpern YS., 1985, Control of utilization of L-arginine, L-ornithine, agmatine, and putrescine as nitrogen sources in Escherichia coli K-12., J Bacteriol 163(3):938-42
[6] Soksawatmaekhin W., Kuraishi A., Sakata K., Kashiwagi K., Igarashi K., 2004, Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli., Mol Microbiol 51(5):1401-12
[7] Tkachenko AG., Akhova AV., Shumkov MS., Nesterova LY., 2012, Polyamines reduce oxidative stress in Escherichia coli cells exposed to bactericidal antibiotics., Res Microbiol 163(2):83-91
[8] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78