RegulonDB RegulonDB 11.0: Gene Form
   

trpC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

trpD trpC trpB trpCp trpCp TSS_1694 TSS_1694 TSS_1693 TSS_1693 TSS_1692 TSS_1692 TSS_1691 TSS_1691 TSS_1690 (cluster) TSS_1690 (cluster) TSS_1689 TSS_1689 TSS_1688 TSS_1688 TSS_1687 TSS_1687 trpAp7 trpAp7 trpAp5 trpAp5 trpAp4 trpAp4 trpAp8 trpAp8

Gene      
Name: trpC    Texpresso search in the literature
Synonym(s): ECK1256, EG11026, b1262, trpCF, trpF
Genome position(nucleotides): 1318427 <-- 1319788
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.79
External database links:  
ASAP:
 ABE-0004238
CGSC:
 72
ECHOBASE:
 EB1019
ECOLIHUB:
 trpC
OU-MICROARRAY:
 b1262
STRING:
 511145.b1262
COLOMBOS: trpC


Product      
Name: fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
Synonym(s): TrpC, TrpF
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 49.492
Isoelectric point: 5.614
Motif(s):
 
Type Positions Sequence Comment
1 -> 257 MMQTVLAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHYASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSALMAHDDLHAAVRRVLLGE UniProt: Indole-3-glycerol phosphate synthase; Sequence Annotation Type: region of interest.
6 -> 252 LAKIVADKAIWVEARKQQQPLASFQNEVQPSTRHFYDALQGARTAFILECKKASPSKGVIRDDFDPARIAAIYKHYASAISVLTDEKYFQGSFNFLPIVSQIAPQPILCKDFIIDPYQIYLARYYQADACLLMLSVLDDDQYRQLAAVAHSLEMGVLTEVSNEEEQERAIALGAKVVGINNRDLRDLSIDLNRTRELAPKLGHNVTVISESGINTYAQVRELSHFANGFLIGSALMAHDDLHAAVRR
31 -> 31 N UniProt: In Ref. 3; CAA23673..
95 -> 95 Q UniProt: In Ref. 1; CAA23664/AAA57299 and 3; CAA23673..
258 -> 453 NKVCGLTRGQDAKAAYDAGAIYGGLIFVATSPRCVNVEQAQEVMAAAPLQYVGVFRNHDIADVVDKAKVLSLAAVQLHGNEEQLYIDTLREALPAHVAIWKALSVGETLPAREFQHVDKYVLDNGQGGSGQRFDWSLLNGQSLGNVLLAGGLGADNCVEAAQTGCAGLDFNSAVESQPGIKDARLLASVFQTLRAY UniProt: N-(5'-phosphoribosyl)anthranilate isomerase; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.15 - tryptophan
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016829 - lyase activity
GO:0016853 - isomerase activity
GO:0016831 - carboxy-lyase activity
GO:0004425 - indole-3-glycerol-phosphate synthase activity
GO:0004640 - phosphoribosylanthranilate isomerase activity
biological_process GO:0008152 - metabolic process
GO:0000162 - tryptophan biosynthetic process
GO:0006568 - tryptophan metabolic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0009073 - aromatic amino acid family biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P00909
ECOCYC:
 PRAI-IGPS
ECOLIWIKI:
 b1262
INTERPRO:
 IPR013785
INTERPRO:
 IPR013798
INTERPRO:
 IPR011060
INTERPRO:
 IPR001468
INTERPRO:
 IPR001240
MODBASE:
 P00909
PDB:
 2KZH
PDB:
 1JCM
PDB:
 1PII
PFAM:
 PF00218
PFAM:
 PF00697
PRIDE:
 P00909
PRODB:
 PRO_000024119
PROSITE:
 PS00614
REFSEQ:
 NP_415778
SMR:
 P00909
UNIPROT:
 P00909


Operon      
Name: trpLEDCBA         
Operon arrangement:
Transcription unit        Promoter
trpCBA
trpL
trpLEDCBA


Transcriptional Regulation      
Display Regulation             
Repressed by: TrpR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter trpAp8 1317241 reverse nd [ICWHO] [1]
  promoter trpAp4 1317303 reverse nd [ICWHO] [1]
  promoter trpAp5 1317306 reverse nd [ICWHO] [1]
  promoter trpAp7 1317339 reverse nd [ICWHO] [1]
  promoter TSS_1687 1317876 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1688 1317878 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1689 1318430 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1690 (cluster) 1318512 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1691 1318516 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1692 1318535 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1693 1318537 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1694 1318607 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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