RegulonDB RegulonDB 11.2: Gene Form
   

trpD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

trpD trpE trpC trpL RydC Cis-reg; leader anti-anti-terminator anti-terminator terminator TSS_1700 TSS_1700 TSS_1699 TSS_1699 TSS_1698 TSS_1698 TSS_1697 TSS_1697 TSS_1696 TSS_1696 TSS_1695 TSS_1695 trpCp trpCp TSS_1694 TSS_1694 TSS_1693 TSS_1693 TSS_1692 TSS_1692 TSS_1691 TSS_1691 TSS_1690 (cluster) TSS_1690 (cluster) TSS_1689 TSS_1689

Gene      
Name: trpD    Texpresso search in the literature
Synonym(s): ECK1257, EG11027, b1263, trpGD
Genome position(nucleotides): 1319789 <-- 1321384
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.39
External database links:  
ASAP:
 ABE-0004241
CGSC:
 71
ECHOBASE:
 EB1020
ECOLIHUB:
 trpD
OU-MICROARRAY:
 b1263
STRING:
 511145.b1263
COLOMBOS: trpD


Product      
Name: anthranilate synthase subunit TrpD
Synonym(s): TrpD, TrpGD, anthranilate synthase component II
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 56.87
Isoelectric point: 6.504
Motif(s):
 
Type Positions Sequence Comment
2 -> 531 ADILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEPANTLQPILEKLYQAQTLSQQESHQLFSAVVRGELKPEQLAAALVSMKIRGEHPNEIAGAATALLENAAPFPRPDYLFADIVGTGGDGSNSINISTASAFVAAACGLKVAKHGNRSVSSKSGSSDLLAAFGINLDMNADKSRQALDELGVCFLFAPKYHTGFRHAMPVRQQLKTRTLFNVLGPLINPAHPPLALIGVYSPELVLPIAETLRVLGYQRAAVVHSGGMDEVSLHAPTIVAELHDGEIKSYQLTAEDFGLTPYHQEQLAGGTPEENRDILTRLLQGKGDAAHEAAVAANVAMLMRLHGHEDLQANAQTVLEVLRSGSAYDRVTALAARG UniProt: Bifunctional protein TrpGD.
3 -> 196 DILLLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGARLLEQTLAWAQQKLEP UniProt: Glutamine amidotransferase type-1.
6 -> 186 LLDNIDSFTYNLADQLRSNGHNVVIYRNHIPAQTLIERLATMSNPVLMLSPGPGVPSEAGCMPELLTRLRGKLPIIGICLGHQAIVEAYGGYVGQAGEILHGKASSIEHDGQAMFAGLTNPLPVARYHSLVGSNIPAGLTINAHFNGMVMAVRHDADRVCGFQFHPESILTTQGARLLEQT
57 -> 59 GPG UniProt: Glutamine binding; Sequence Annotation Type: region of interest.
61 -> 61 P UniProt: In Ref. 2; CAA23665..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.15 - tryptophan
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0005950 - anthranilate synthase complex
molecular_function GO:0003824 - catalytic activity
GO:0016757 - glycosyltransferase activity
GO:0016740 - transferase activity
GO:0016829 - lyase activity
GO:0004048 - anthranilate phosphoribosyltransferase activity
GO:0004049 - anthranilate synthase activity
GO:0000287 - magnesium ion binding
biological_process GO:0008152 - metabolic process
GO:0000162 - tryptophan biosynthetic process
GO:0006541 - glutamine metabolic process
GO:0008652 - cellular amino acid biosynthetic process
GO:0009073 - aromatic amino acid family biosynthetic process
GO:0002047 - phenazine biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P00904
ECOCYC:
 ANTHRANSYNCOMPII-MONOMER
ECOLIWIKI:
 b1263
INTERPRO:
 IPR035902
INTERPRO:
 IPR000312
INTERPRO:
 IPR029062
INTERPRO:
 IPR017926
INTERPRO:
 IPR017459
INTERPRO:
 IPR036320
INTERPRO:
 IPR005940
INTERPRO:
 IPR006221
MODBASE:
 P00904
PFAM:
 PF02885
PFAM:
 PF00117
PFAM:
 PF00591
PRIDE:
 P00904
PRODB:
 PRO_000024120
PROSITE:
 PS51273
REFSEQ:
 NP_415779
SMR:
 P00904
SWISSMODEL:
 P00904
UNIPROT:
 P00904


Operon      
Name: trpLEDCBA         
Operon arrangement:
Transcription unit        Promoter
trpCBA
trpL
trpLEDCBA


Transcriptional Regulation      
Display Regulation             
Repressed by: TrpR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1689 1318430 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1690 (cluster) 1318512 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1691 1318516 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1692 1318535 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1693 1318537 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1694 1318607 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1695 1321481 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1696 1321882 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1697 1321905 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1698 1322038 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1699 1322047 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_1700 1322139 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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