Gene
Name:	uidA
Synonym(s):	ECK1612, EG11055, b1617, gurA, gusA
Genome position(nucleotides):	1694260 <-- 1696071 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	52.26
External database links:

ASAP:	ABE-0005410
CGSC:	36
ECHOBASE:	EB1048
ECOLIHUB:	uidA
MIM:	253220
OU-MICROARRAY:	b1617
STRING:	511145.b1617
COLOMBOS:	uidA

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	uidCp5	1692988		reverse	nd	[ICWHO]	[14]
	promoter	uidCp6	1693006		reverse	nd	[ICWHO]	[14]

Reference(s)
[1] Ahmad S., Hughes MA., Yeh LA., Scott JE., 2012, Potential repurposing of known drugs as potent bacterial β-glucuronidase inhibitors., J Biomol Screen 17(7):957-65
[2] Borisenkov MF., Bakutova LA., Latkin DS., Golovchenko VV., Vityazev FV., 2011, Interaction of microbial β-glucuronidase with vegetable pectins., J Agric Food Chem 59(18):9922-6
[3] Briciu-Burghina C., Heery B., Regan F., 2015, Continuous fluorometric method for measuring β-glucuronidase activity: comparative analysis of three fluorogenic substrates., Analyst 140(17):5953-64
[4] Deckert K., Budiardjo SJ., Brunner LC., Lovell S., Karanicolas J., 2012, Designing allosteric control into enzymes by chemical rescue of structure., J Am Chem Soc 134(24):10055-60
[5] Khan KM., Fakhri MI., Shaikh NN., Saad SM., Hussain S., Perveen S., Choudhary MI., 2014, β-glucuronidase inhibitory studies on coumarin derivatives., Med Chem 10(8):778-82
[6] Kong R., Liu T., Zhu X., Ahmad S., Williams AL., Phan AT., Zhao H., Scott JE., Yeh LA., Wong ST., 2014, Old drug new use--amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity., Clin Cancer Res 20(13):3521-30
[7] LoGuidice A., Wallace BD., Bendel L., Redinbo MR., Boelsterli UA., 2012, Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice., J Pharmacol Exp Ther 341(2):447-54
[8] Man S., Cheng R., Miao C., Gong Q., Gu Y., Lu X., Han F., Yu W., 2011, Artificial trans-encoded small non-coding RNAs specifically silence the selected gene expression in bacteria., Nucleic Acids Res 39(8):e50
[9] Novel M., Novel G., 1974, [Escherichia coli K 12 mutants, able to grow on methyl-beta-galacturonide: simple constitutive mutants for the synthesis of beta-glucuronidase and double mutants also derepressed for the synthesis of 2 enzymes for glucuronate utilization]., C R Acad Sci Hebd Seances Acad Sci D 279(8):695-8
[10] Novel M., Novel G., 1976, Regulation of beta-glucuronidase synthesis in Escherichia coli K-12: constitutive mutants specifically derepressed for uidA expression., J Bacteriol 127(1):406-17
[11] Novel M., Novel G., 1976, Regulation of beta-glucuronidase synthesis in Escherichia coli K-12: pleiotropic constitutive mutations affecting uxu and uidA expression., J Bacteriol 127(1):418-32
[12] Rasmussen TS., Koldso H., Nakagawa S., Kato A., Schiott B., Jensen HH., 2011, Synthesis of uronic-noeurostegine--a potent bacterial β-glucuronidase inhibitor., Org Biomol Chem 9(22):7807-13
[13] Wilkinson SM., Watson MA., Willis AC., McLeod MD., 2011, Experimental and kinetic studies of the Escherichia coli glucuronylsynthase: an engineered enzyme for the synthesis of glucuronide conjugates., J Org Chem 76(7):1992-2000
[14] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	UidR, UxuR