RegulonDB

Gene
Name:	xseA
Synonym(s):	ECK2505, EG11072, b2509, xse
Genome position(nucleotides):	2634232 --> 2635602 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.25
External database links:

ASAP:	ABE-0008263
CGSC:	6
ECHOBASE:	EB1065
OU-MICROARRAY:	b2509
PortEco:	xseA
STRING:	511145.b2509
COLOMBOS:	xseA

Product

Name:

exodeoxyribonuclease VII subunit XseA

Synonym(s):

Xse, XseA, exonuclease VII, large subunit

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

51.832

Isoelectric point:

10.555

Motif(s):

Type	Positions	Sequence
	10 -> 103	FTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQ
	126 -> 440	LFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPAAVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFTSRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSTRQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLQKRMSFALENQLKRTGQQQQRLTQRLNQQNPQPKIHRAQTRIQQLEYRLAETLRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKVKQVKAGEMLTTRLEDGWIES
	67 -> 67	N

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.2 - DNA
		2 - information transfer --> 2.1 - DNA related --> 2.1.5 - DNA degradation
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0009318 - exodeoxyribonuclease VII complex
	molecular_function	GO:0003676 - nucleic acid binding GO:0004518 - nuclease activity GO:0004527 - exonuclease activity GO:0005515 - protein binding GO:0016787 - hydrolase activity GO:0008855 - exodeoxyribonuclease VII activity
	biological_process	GO:0006308 - DNA catabolic process GO:0090305 - nucleic acid phosphodiester bond hydrolysis

Note(s):

Note(s): ...[more].

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MINT:

PANTHER:

PFAM:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

xseA

Operon arrangement:

Transcription unit	Promoter
xseA	xseAp

Transcriptional Regulation
	Display Regulation
Activated by:	MarA
Repressed by:	CRP

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_2785	2633290	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_2786	2634070	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_2787	2634090	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_2788 (cluster)	2634100	reverse	For this promoter, there is a cluster of 3 transcription start sites,in the interval 2634098 to 2634100, where the highest frequency is at position 2632120. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
promoter	TSS_2789	2634102	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_2790	2634105	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_2792	2636300	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_2793	2636452	reverse	nd	[RS-EPT-CBR]	[1]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.