RegulonDB RegulonDB 11.1: Gene Form
   

hisL gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hisG yefM hisL yoeB YefM-YoeB YefM YefM-YoeB YefM DksA-ppGpp DksA-ppGpp Cis-reg; leader terminator anti-terminator anti-anti-terminator TSS_2343 TSS_2343 TSS_2342 TSS_2342 TSS_2341 TSS_2341 TSS_2340 TSS_2340 TSS_2339 TSS_2339 TSS_2338 TSS_2338 TSS_2337 TSS_2337 TSS_2336 TSS_2336 TSS_2335 TSS_2335 TSS_2334 TSS_2334 TSS_2333 TSS_2333 TSS_2332 TSS_2332 TSS_2331 (cluster) TSS_2331 (cluster) TSS_2330 (cluster) TSS_2330 (cluster) TSS_2329 TSS_2329 hisLp hisLp TSS_2327 TSS_2327 yefMp yefMp TSS_2325 TSS_2325

Gene      
Name: hisL    Texpresso search in the literature
Synonym(s): ECK2013, EG11269, b2018
Genome position(nucleotides): 2089996 --> 2090046
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 43.14
External database links:  
ASAP:
 ABE-0006710
ECHOBASE:
 EB1248
ECOLIHUB:
 hisL
OU-MICROARRAY:
 b2018
STRING:
 511145.b2018
COLOMBOS: hisL


Product      
Name: his operon leader peptide
Synonym(s): HisL
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 2.081
Isoelectric point: 9.706
Motif(s):
 
Type Positions Sequence Comment
1 -> 16 MTRVQFKHHHHHHHPD

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.16 - histidine
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
biological_process GO:0000105 - histidine biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P60995
ECOCYC:
 EG11269-MONOMER
ECOLIWIKI:
 b2018
INTERPRO:
 IPR012565
PFAM:
 PF08047
PRIDE:
 P60995
REFSEQ:
 NP_416522
UNIPROT:
 P60995


Operon      
Name: hisLGDCBHAFI         
Operon arrangement:
Transcription unit        Promoter
hisL
hisLGDCBHAFI
hisBHAFI


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2325 2089731 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2327 2089902 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2329 2089980 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2330 (cluster) 2089990 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2331 (cluster) 2089999 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2332 2090173 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2333 2090363 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2334 2090601 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2335 2090638 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2336 2090650 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2337 2090803 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2338 2090809 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2339 2090819 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2340 2091010 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2341 2091072 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2342 2091081 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2343 2091087 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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