RegulonDB RegulonDB 10.9: Gene Form
   

ilvL gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

yifB ilvL ilvX Lrp Lrp Lrp IHF IHF ppGpp TSS_4382 (cluster) TSS_4382 (cluster) TSS_4381 TSS_4381 TSS_4380 (cluster) TSS_4380 (cluster) TSS_4379 TSS_4379 TSS_4378 TSS_4378 TSS_4377 (cluster) TSS_4377 (cluster) TSS_4376 (cluster) TSS_4376 (cluster) TSS_4375 TSS_4375 TSS_4374 TSS_4374 TSS_4373 TSS_4373 ilvLp2 ilvLp2 ilvLp1 ilvLp1 yifBp6 yifBp6 yifBp8 yifBp8 yifBp9 yifBp9

Gene      
Name: ilvL    Texpresso search in the literature
Synonym(s): ECK3759, EG11270, b3766
Genome position(nucleotides): 3950322 --> 3950420 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.54
External database links:  
ASAP:
ABE-0012307
ECHOBASE:
EB1249
ECOLIHUB:
ilvL
OU-MICROARRAY:
b3766
STRING:
511145.b3766
COLOMBOS: ilvL


Product      
Name: ilvXGMEDA operon leader peptide
Synonym(s): IlvL
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 3.231
Isoelectric point: 11.477
Motif(s):
 
Type Positions Sequence
1 -> 32 MTALLRVISLVVISVVVIIIPPCGAALGRGKA

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.18 - isoleucine/valine
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
biological_process GO:0008652 - cellular amino acid biosynthetic process
GO:0009082 - branched-chain amino acid biosynthetic process
GO:0009099 - valine biosynthetic process
GO:0031555 - transcriptional attenuation
Note(s): Note(s): ...[more].
Evidence: [IDA] Inferred from direct assay
Reference(s): [1] Lawther RP., et al., 1980
External database links:  
ECOCYC:
EG11270-MONOMER
ECOLIWIKI:
b3766
INTERPRO:
IPR012567
PFAM:
PF08046
PRIDE:
P62522
REFSEQ:
NP_418215
UNIPROT:
P62522


Operon      
Name: ilvLXGMEDA         
Operon arrangement:
Transcription unit        Promoter
ilvL
ilvLXG_1G_2MEDA
ilvL
ilvLXG_1G_2MEDA
ilvEDA
ilvA


Transcriptional Regulation      
Display Regulation             
Activated by: IHF
Repressed by: IHF, Lrp


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yifBp9 3949984 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter yifBp8 3950027 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter yifBp6 3950175 reverse Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_4373 3950322 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4374 3950325 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4375 3950477 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4376 (cluster) 3950479 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4377 (cluster) 3950482 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4378 3950485 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4379 3950487 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4380 (cluster) 3950489 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4381 3950511 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4382 (cluster) 3950539 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Lawther RP., Hatfield GW., 1980, Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12., Proc Natl Acad Sci U S A 77(4):1862-6

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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