RegulonDB

Gene
Name:	ilvL
Synonym(s):	ECK3759, EG11270, b3766
Genome position(nucleotides):	3950322 --> 3950420
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.54
External database links:

ASAP:	ABE-0012307
ECHOBASE:	EB1249
ECOLIHUB:	ilvL
OU-MICROARRAY:	b3766
STRING:	511145.b3766
COLOMBOS:	ilvL

Product

Name:

ilvXGMEDA operon leader peptide

Synonym(s):

IlvL

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

3.231

Isoelectric point:

11.477

Motif(s):

Type	Positions	Sequence	Comment
	1 -> 32	MTALLRVISLVVISVVVIIIPPCGAALGRGKA

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.18 - isoleucine/valine
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	biological_process	GO:0008652 - cellular amino acid biosynthetic process GO:0009082 - branched-chain amino acid biosynthetic process GO:0009099 - valine biosynthetic process GO:0031555 - transcriptional attenuation

Note(s):

Note(s): ...[more].

Evidence:

[EXP-IDA] Inferred from direct assay

Reference(s):

[1] Lawther RP., et al., 1980

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PFAM:

PRIDE:

REFSEQ:

UNIPROT:

Operon

Name:

ilvLXGMEDA

Operon arrangement:

Transcription unit	Promoter
ilvL	ilvLp1
ilvLXG_1G_2MEDA	ilvLp1
ilvL	ilvLp2
ilvLXG_1G_2MEDA	ilvLp2
ilvEDA	ilvEp3
ilvA	ilvAp

Transcriptional Regulation
	Display Regulation
Activated by:	IHF
Repressed by:	IHF, Lrp

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	yifBp9	3949984	reverse	nd	[COMP-AINF]	[2]
promoter	yifBp8	3950027	reverse	nd	[COMP-AINF]	[2]
promoter	yifBp6	3950175	reverse	nd	[COMP-AINF]	[2]
promoter	TSS_4373	3950322	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4374	3950325	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4375	3950477	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4376 (cluster)	3950479	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4377 (cluster)	3950482	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4378	3950485	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4379	3950487	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4380 (cluster)	3950489	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4381	3950511	forward	nd	[RS-EPT-CBR]	[3]
promoter	TSS_4382 (cluster)	3950539	forward	nd	[RS-EPT-CBR]	[3]

Evidence
[COMP-AINF] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Lawther RP., Hatfield GW., 1980, Multivalent translational control of transcription termination at attenuator of ilvGEDA operon of Escherichia coli K-12., Proc Natl Acad Sci U S A 77(4):1862-6
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.