RegulonDB

RegulonDB RegulonDB 10.9: Gene Form

fabZ gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	fabZ
Synonym(s):	ECK0179, EG11284, b0180, sabA1, sefA, sfhC21, yaeA
Genome position(nucleotides):	202101 --> 202556 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.44
External database links:

ASAP:	ABE-0000613
CGSC:	30597
ECHOBASE:	EB1261
ECOLIHUB:	fabZ
OU-MICROARRAY:	b0180
STRING:	511145.b0180
COLOMBOS:	fabZ

Product

Name:

3-hydroxy-acyl-[acyl-carrier-protein] dehydratase

Synonym(s):

FabZ, SefA, YaeA

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

17.033

Isoelectric point:

7.512

Motif(s):

Type	Positions	Sequence
	85 -> 85	L
	17 -> 141	LPHRFPFLLVDRVLDFEEGRFLRAVKNVSVNEPFFQGHFPGKPIFPGVLILEAMAQATGILAFKSVGKLEPGELYYFAGIDEARFKRPVVPGDQMIMEVTFEKTRRGLTRFKGVALVDGKVVCEA

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.4 - fatty acids and phosphatidic acid
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0008659 - (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity GO:0004317 - 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0016829 - lyase activity GO:0016836 - hydro-lyase activity GO:0008693 - 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity GO:0019171 - 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity GO:0042802 - identical protein binding GO:0047451 - 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
	biological_process	GO:0006629 - lipid metabolic process GO:0009245 - lipid A biosynthetic process GO:0006633 - fatty acid biosynthetic process

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PANTHER:

PDB:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

SWISSMODEL:

UNIPROT:

Operon

Name:

bamA-skp-lpxD-fabZ-lpxAB-rnhB-dnaE

Operon arrangement:

Transcription unit	Promoter
bamA-hlpA-lpxD-fabZ-lpxAB-rnhB-dnaE	bamAp2
bamA	bamAp
hlpA-lpxD-fabZ-lpxA	hlpAp
lpxD	lpxDp
fabZ

Transcriptional Regulation
	Display Regulation
Activated by:	CpxR, GadE

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	TSS_367	201749		forward	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_368	201767		reverse	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_369 (cluster)	202019		forward	For this promoter, there is a cluster of 3 transcription start sites,in the interval 202019 to 202021, where the highest frequency is at position 202019. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
	promoter	TSS_370 (cluster)	202063		forward	For this promoter, there is a cluster of 6 transcription start sites,in the interval 202063 to 202068, where the highest frequency is at position 202066. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
	promoter	TSS_371 (cluster)	202070		forward	For this promoter, there is a cluster of 7 transcription start sites,in the interval 202070 to 202076, where the highest frequency is at position 202072. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
	promoter	TSS_372 (cluster)	202078		forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 202078 to 202079, where the highest frequency is at position 202079. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
	promoter	TSS_373 (cluster)	202081		forward	For this promoter, there is a cluster of 3 transcription start sites,in the interval 202081 to 202083, where the highest frequency is at position 202082. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
	promoter	TSS_374	202087		forward	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_375	202110		forward	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_376	202370		forward	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_377	202372		forward	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_378	202585		forward	nd	[RS-EPT-CBR]	[1]
	promoter	TSS_379	202645		forward	nd	[RS-EPT-CBR]	[1]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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