RegulonDB RegulonDB 10.8: Gene Form
   

cydD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cydD cydC trxB NarL FNR NarL anti-anti-terminator anti-terminator terminator cydDp cydDp TSS_1059 TSS_1059 TSS_1058 TSS_1058 cydCp5 cydCp5 TSS_1057 TSS_1057

Gene      
Name: cydD    Texpresso search in the literature
Synonym(s): ECK0878, EG11405, b0887, htrD
Genome position(nucleotides): 929196 <-- 930962 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.65
External database links:  
ASAP:
 ABE-0003015
CGSC:
 31720
ECHOBASE:
 EB1377
OU-MICROARRAY:
 b0887
PortEco:
 cydD
STRING:
 511145.b0887
COLOMBOS: cydD


Product      
Name: glutathione/L-cysteine ABC exporter subunit CydD
Synonym(s): CydD, HtrD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 65.056
Isoelectric point: 6.389
Motif(s):
 
Type Positions Sequence
29 -> 49 LLGFVSGILIIAQAWFMARIL
64 -> 64 L
350 -> 583 IEAEELFITSPEGKTLAGPLNFTLPAGQRAVLVGRSGSGKSSLLNALSGFLSYQGSLRINGIELRDLSPESWRKHLSWVGQNPQLPAATLRDNVLLARPDASEQELQAALDNAWVSEFLPLLPQGVDTPVGDQAARLSVGQAQRVAVARALLNPCSLLLLDEPAASLDAHSEQRVMEALNAASLRQTTLMVTHQLEDLADWDVIWVMQDGRIIEQGRYAELSVAGGPFATLLAH
427 -> 427 W
24 -> 316 LNISRLLGFVSGILIIAQAWFMARILQHMIMENIPREALLLPFTLLVLTFVLRAWVVWLRERVGYHAGQHIRFAIRRQVLDRLQQAGPAWIQGKPAGSWATLVLEQIDDMHDYYARYLPQMALAVSVPLLIVVAIFPSNWAAALILLGTAPLIPLFMALVGMGAADANRRNFLALARLSGHFLDRLRGMETLRIFGRGEAEIESIRSASEDFRQRTMEVLRLAFLSSGILEFFTSLSIALVAVYFGFSYLGELDFGHYDTGVTLAAGFLALILAPEFFQPLRDLGTFYHAKAQ

 
Classification:
Multifun Terms (GenProtEC)  
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.am - ABC superfamily, ATP binding and membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0005623 - cell
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
molecular_function GO:0016887 - ATPase activity
GO:0042626 - ATPase-coupled transmembrane transporter activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
biological_process GO:0045454 - cell redox homeostasis
GO:0055085 - transmembrane transport
GO:0033228 - cysteine export across plasma membrane
GO:0042883 - cysteine transport
GO:0034775 - glutathione transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
DIP:
 DIP-9363N
ECOCYC:
 CYDD-MONOMER
ECOLIWIKI:
 b0887
INTERPRO:
 IPR014216
INTERPRO:
 IPR039421
INTERPRO:
 IPR036640
INTERPRO:
 IPR027417
INTERPRO:
 IPR017871
INTERPRO:
 IPR011527
INTERPRO:
 IPR003593
INTERPRO:
 IPR003439
MODBASE:
 P29018
PANTHER:
 PTHR24221
PFAM:
 PF00005
PFAM:
 PF00664
PRIDE:
 P29018
PRODB:
 PRO_000022364
PROSITE:
 PS50893
PROSITE:
 PS00211
PROSITE:
 PS50929
REFSEQ:
 NP_415407
SMART:
 SM00382
SMR:
 P29018
UNIPROT:
 P29018


Operon      
Name: cydDC         
Operon arrangement:
Transcription unit        Promoter
cydDC


Transcriptional Regulation      
Display Regulation             
Activated by: FNR, NarL, ArcA


RNA cis-regulatory element    
Attenuation: Transcriptional


Regulation by small RNA    
  Display Regulation
small RNA fnrS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1057 928505 reverse nd [RS-EPT-CBR] [2]
  promoter cydCp5 929400 reverse Similarity to the consensus
Read more > 		[ICWHO] [3]
  promoter TSS_1058 929741 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_1059 930998 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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