RegulonDB

Gene
Name:	marR
Synonym(s):	ECK1523, EG11435, b1530, cfxB, inaR, soxQ
Genome position(nucleotides):	1619120 --> 1619554
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	49.43
External database links:

ASAP:	ABE-0005110
CGSC:	30935
ECHOBASE:	EB1405
ECOLIHUB:	marR
OU-MICROARRAY:	b1530
STRING:	511145.b1530
COLOMBOS:	marR

Shine dalgarno
Sequence:	attacttgccAGGGCAactaatGTG

Product

Name:

DNA-binding transcriptional repressor MarR

Synonym(s):

CfxB, InaR, MarR, SoxQ

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

MarR

Cellular location:

cytosol

Molecular weight:

16.065

Isoelectric point:

8.375

Motif(s):

Type	Positions	Sequence	Comment
	11 -> 144	IIPLGRLIHMVNQKKDRLLNEYLSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTGGAAICEQCHQLVGQDLHQELTKNLTADEVATLEYLLKKVLP	UniProt: HTH marR-type.
	38 -> 96	ITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGV
	45 -> 45	V	UniProt: Increased transcription of the region II transcript..
	77 -> 77	R	UniProt: Increased transcription of the region II transcript..
	123 -> 144	LTKNLTADEVATLEYLLKKVLP	UniProt: Increased transcription of the region II transcript..

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
		5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0009408 - response to heat GO:0045892 - negative regulation of transcription, DNA-templated GO:0046677 - response to antibiotic GO:0071236 - cellular response to antibiotic

Note(s):

Note(s): ...[more].

Reference(s):

[1] Ariza RR., et al., 1994
[2] Cohen SP., et al., 1993
[3] Sulavik MC., et al., 1995

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PDB:

PDB:

PDB:

PDB:

PDB:

PFAM:

PRIDE:

PRINTS:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	MarA, CRP, CpxR, SoxS, Rob, Fis
Repressed by:	Cra, AcrR, MarR

Reference(s)
[1] Ariza RR., Cohen SP., Bachhawat N., Levy SB., Demple B., 1994, Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli., J Bacteriol 176(1):143-8
[2] Cohen SP., Hachler H., Levy SB., 1993, Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli., J Bacteriol 175(5):1484-92
[3] Sulavik MC., Gambino LF., Miller PF., 1995, The MarR repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli: prototypic member of a family of bacterial regulatory proteins involved in sensing phenolic compounds., Mol Med 1(4):436-46